1966
DOI: 10.1111/j.1749-6632.1966.tb45461.x
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Abstract: The discovery that there are characteristic abnormalities in the intramuscular nerve endings in myasthenia gravis provides yet another of the surprises which are responsible for much of the fascination of the story of this disease. The surprise should not, however, have been a total one since Buzzard, in the course of his report on the lymphorrhages of myasthenia gravis sixty years ago, wrote:There can be little doubt that the methods a t our disposal for the examination of the axis cylinders in nerve trunks, … Show more

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Cited by 47 publications
(5 citation statements)
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“…(3) Elaborate terminal arborization with occasional "multibranching" appeared to arise from a progressive growth of sprouts. Endplates resembling this profile have been described in myasthenia gravis in humans (Woolf, 1966). We suggest that the elaborate terminal arborization as well as the ectopic endings may result from a response to the increased demands to regenerate.…”
Section: Table III Effects Of a Single Subcutaneous Injection Of Sarsupporting
confidence: 68%
“…(3) Elaborate terminal arborization with occasional "multibranching" appeared to arise from a progressive growth of sprouts. Endplates resembling this profile have been described in myasthenia gravis in humans (Woolf, 1966). We suggest that the elaborate terminal arborization as well as the ectopic endings may result from a response to the increased demands to regenerate.…”
Section: Table III Effects Of a Single Subcutaneous Injection Of Sarsupporting
confidence: 68%
“…In addition, there was an increased number of large mitochondria with rarefied cristae in the axonal terminals. These characteristics are somewhat reminiscent of classic findings in myasthenia gravis (Woolf, ; Hong et al ., ), which might reflect or be a consequence of a possible defect in synaptic transmission (Fig. ).…”
Section: Resultsmentioning
confidence: 98%
“…Morphologic as well as functional evidence points to a presynaptic lesion in myasthenia gravis Coers & Desmedt, 1959;MacDermot, 1960;Desmedt, 1965;Thesleff, 1965;Woolf, 1965). Facilitatory drugs, by prolonging the terminal action potential, could provide for the maintenance of propagation and, thus, transmission.…”
Section: Soleus Musclementioning
confidence: 99%