1990
DOI: 10.1111/j.1471-4159.1990.tb02325.x
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Abstract: The structure and function of mitochondrial respiratory-chain enzyme proteins were studied postmortem in the substantia nigra of nine patients with Parkinson's disease and nine matched controls. Total protein and mitochondrial mass were similar in the two groups. NADH-ubiquinone reductase (Complex I) and NADH cytochrome c reductase activities were significantly reduced, whereas succinate cytochrome c reductase activity was normal. These results indicated a specific defect of Complex I activity in the substanti… Show more

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Cited by 2,139 publications
(1,394 citation statements)
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“…Reduced activity level and reduced amount of mitochondrial complex I have been reported in PD patients [17][18][19][20][21] and in animal models [22,23]. These findings indicate that the function of mitochondrial complex I is related to the onset of PD.…”
Section: Introductionmentioning
confidence: 71%
“…Reduced activity level and reduced amount of mitochondrial complex I have been reported in PD patients [17][18][19][20][21] and in animal models [22,23]. These findings indicate that the function of mitochondrial complex I is related to the onset of PD.…”
Section: Introductionmentioning
confidence: 71%
“…Moreover, MPP ÷ caused extensive oxidation of cytochrome b in rat striatal slices, as expected if the toxin interrupted electron flux from NADH dehydrogenase to Q. More recent evidence has come from the finding of mitochondrial abnormalities in the nigral neurons of MPTP treated monkeys [39] and Complex I deficiency in the nigrostriatum of parkinsonism patients [40,41]. The fact that MPP ÷ and its analogs compete with the respiratory chain inhibitors rotenone and piericidin for binding to NADH dehydrogenase (cf.…”
Section: The Mitochondrial Hypothesismentioning
confidence: 93%
“…However, this does not fully account for the 102-103-fold lowering of the IC5o value for the inhibition of mitochondrial respiration. The second effect was noted [41,45] in studies of inverted submitochondrial particles, in which the rotenone site of NADH dehydrogenase is exposed to the cytoplasm. In such preparations TPB-potentiated the inhibitory effect of MPP ÷ by one order of magnitude and that of some MPP ÷ analogs by 2 orders of magnitude.…”
Section: From Accumulation In Mitochondria To Cell Deathmentioning
confidence: 96%
“…The disease is believed to be a result of genetic predisposition or environmental factors (Corrigan et al , 1998) that lead to oxidative damage of mitochondrial proteins (Alam et al , 1997) and subsequent mitochondrial dysfunction (Schapira et al , 1990) and is characterized in patients by the loss of dopaminergic neurons in the substantia nigra of the midbrain (Hornykiewicz, 1966; Riederer & Wuketich, 1976). In addition to sporadic Parkinson's disease, there are also genetic forms of the disease that account for approximately 10% of all cases.…”
Section: Introductionmentioning
confidence: 99%