2007
DOI: 10.1111/j.1468-3083.2007.02202.x
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Abstract: Objective To identify pathoaetiological neuroimmune mechanisms in patients with atopic dermatitis (AD) and chronic stress, focusing at nerve density, sensory neuropeptides, and the serotonergic system. Methods Eleven patients with AD with histories of stress worsening were included. Biopsies from involved and non-involved skin were processed for immunohistochemistry. Salivary cortisol test was done as a marker for chronic stress. Results There were more acanthosis and fewer nerve fibres in epidermis and papill… Show more

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Cited by 53 publications
(39 citation statements)
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References 36 publications
(58 reference statements)
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“…(3)(4)(5)(6) For the majority of patients onset/flare up of their lesions is directly associated with stressful life events. (3,4) In response to stressful stimuli the sympathetic nervous system releases catecholamines that can push immunological responses towards the Th2 phenotype.…”
Section: Introductionmentioning
confidence: 99%
“…(3)(4)(5)(6) For the majority of patients onset/flare up of their lesions is directly associated with stressful life events. (3,4) In response to stressful stimuli the sympathetic nervous system releases catecholamines that can push immunological responses towards the Th2 phenotype.…”
Section: Introductionmentioning
confidence: 99%
“…In an immunohistochemical analysis of patients with stress-associated AD, there was increased positive staining for mast cells, serotonin receptor subtypes 5-HT1A and 5-HT2A, and serotonin transporter protein (SERT) observed in lesional compared with non-involved skin (64). In this study, low cortisol ratios were an indicator of chronic stress, and correlated with the degree of serotonin receptor positive staining in the papillary dermis of involved skin.…”
Section: Resultsmentioning
confidence: 99%
“…Thus it seems quite reasonable that neuromediators are involved in the pathogenesis of pruritus in AD (Roosterman et al , 2006). Actually, stressed patients with AD had increased numbers of 5-HT-receptive mast cells (Lonne-Rahm et al , 2008).…”
Section: Interactions Between Nervous System and Immune System In Atomentioning
confidence: 99%