2010
DOI: 10.1111/j.1440-1827.2010.02534.x
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Abstract: Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as one of the most common genetic alterations in malignant mesotheliomas (MMs). Previous studies showed that this alteration might be useful for differentiating benign from malignant mesothelial tumors in cytology and surgical specimens. Although the diagnostic utility of 9p21 homozygous deletion by fluorescence in situ hybridization (FISH) analysis has been reported only recently, it has not been well demonstrated. The purpose of… Show more

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Cited by 71 publications
(55 citation statements)
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“…In their study, no cases of reactive pleural mesothelial proliferations showed p16 deletion, and the authors suggested that 9p21 homozygous deletion by FISH might be helpful to differentiate malignant mesotheliomas from reactive mesothelial proliferations. Our study confirmed this observation in Japanese cases of MM 12. A 22q loss was examined in 38% cases of MM by CGH 24.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…In their study, no cases of reactive pleural mesothelial proliferations showed p16 deletion, and the authors suggested that 9p21 homozygous deletion by FISH might be helpful to differentiate malignant mesotheliomas from reactive mesothelial proliferations. Our study confirmed this observation in Japanese cases of MM 12. A 22q loss was examined in 38% cases of MM by CGH 24.…”
Section: Discussionsupporting
confidence: 88%
“…Recently, Chiosea et al reported that 9p21 homozygous deletion using fluorescence in situ hybridisation (FISH) analysis is helpful for differentiating malignant mesothelioma from benign reactive lesions 11. Similarly, we examined 9p21 deletion by FISH analysis in 88% of MM cases in a previous report 12. This observation has opened a new avenue for surgical pathologists in resolving diagnostic dilemmas in mesothelial pathology.…”
Section: Introductionmentioning
confidence: 70%
“…12 In fact, a variety of markers, such as desmin, epithelial membrane antigen, p53, IMP3, GLUT-1, CD146, and CD147, have been evaluated on both tissue and cytological samples, but none of them appeared to achieve sufficient diagnostic adequacy in the separation between malignant and benign mesothelial lesions. Using fluorescence in situ hybridization (FISH), the homozygous deletion of CDKN2A gene is found in 52-88% of mesotheliomas, but not in reactive mesothelial proliferations; 23,37-39 using a cut-off value of 10% positive mesothelial cells, p16 protein expression resulted to be closely related to CDKN2A status in some, 23,38 but not all, studies, 37 thus hampering its use as a reliable marker to distinguish mesothelioma from reactive mesothelial proliferations.…”
mentioning
confidence: 99%
“…These findings have been confirmed by a further investigation in which FISH analysis demonstrated 9p21 deletion in 35 of 40 MM cases (88%) and absence of this deletion in cases of adenomatoid tumor, benign mesothelial multicystic tumor, reactive mesothelial hyperplasia, or pleuritis. 48 However, it is worth emphasizing that deletion of 9p21 is a crucial event for the development of a variety of human cancers 49 and therefore, it is not a helpful clue for differentiating MM from nonmesothelial tumors involving serosal membranes.…”
Section: Ink4amentioning
confidence: 99%