Pediatric Allergy and Immunology volume 17, issue 7, P477-483 2006 DOI: 10.1111/j.1399-3038.2006.00456.x

The vitamin D slant on allergy

Matthias Wjst
Abstract: Oral vitamin D supplementation has been introduced into modern medicine to prevent rickets without the knowledge that this may have profound immunological consequences. The main vitamin D metabolite calcitriol suppresses dendritic cell maturation and consecutive Th(1) cell development, which has independently described as a key mechanism of allergy development. Animal studies and epidemiological surveys now provide a first link of early vitamin D supplementation and later allergy where several vitamin D regulated genes seem to be involved. A randomized clinical trial of vitamin D supplementation could be a further step to follow up the vitamin hypothesis.
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