The vitamin D slant on allergy

Wjst, Matthias

doi:10.1111/j.1399-3038.2006.00456.x

Cited by 83 publications

(68 citation statements)

References 107 publications

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“…Although most reports suggest a role for vitamin D in asthma control, others show that vitamin D may promote, rather than ameliorate, the asthma phenotype. 42,43 These differences have also been reported regarding the effects of vitamin D on Th2 cell responses. One study addressing this issue reported that vitamin D supplementation through the first year of life (2,000 IU/d) elicited an increased rather than decreased risk of developing atopy, allergic rhinitis, and asthma in adulthood.…”

Section: F Enomentioning

confidence: 90%

Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma

et al. 2015

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Section: F Enomentioning

confidence: 90%

Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma

et al. 2015

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“…Vitamin D has been shown to inhibit the maturation of dendritic cells and impede the development of T-helper 1 responses. In theory, vitamin D therefore could increase the risk of allergic disorders in infancy [103]. This is supported by a recent German birth cohort study (LINA study) which found that high vitamin D levels during pregnancy and at birth were associated with an increased risk of food allergy [104].…”

Section: Vitamin D Hypothesismentioning

(Expert classified)

Food Allergy Prevention and Treatment by Targeted Nutrition

Heine¹

2018

Ann Nutr Metab

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In view of the dramatic rise in the prevalence of food allergy globally, effective prevention strategies have become a public health priority. Several models have emerged around the etiology of food allergy, including the hygiene hypothesis, dual allergen exposure hypothesis, and vitamin D hypothesis. These form the basis for current and potential prevention strategies. Breastfeeding remains a key pillar of primary allergy prevention. Other nutritional interventions, including the use of whey-based, partially hydrolyzed formula in non-breastfed infants, also play an important role. In recent years, there has been a shift away from prolonged food allergen avoidance to the proactive allergen introduction from 4 months of age. This approach is supported by 2 pivotal randomized clinical trials showing that the early introduction of peanut and other food allergens significantly reduces the risk of food allergy. However, the implementation of this strategy at the population level still raises significant logistic problems, including patient selection and development of suitable food formats for young infants. Other prevention strategies, including vitamin D supplementation, are currently under evaluation. Maternal elimination diets during pregnancy and lactation are not recommended for allergy prevention. The treatment of food allergies has also seen major transformations. While strict allergen avoidance is still the key treatment principle, there is a greater focus on desensitization and tolerance induction by oral and epicutaneous immunotherapy. In addition, specialized hypoallergenic infant formulas for the treatment of infants with cow’s milk allergy have undergone reformulation, including the addition of lactose and probiotics in order to modulate the gut microbiome and early immune responses. Further research is needed to inform the most effective food allergy prevention strategies at the population level. In addition, the wider application of food allergen immunotherapy may provide better health outcomes and improved quality of life for families affected by food allergies.

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“…Intraperitoneal administration of RvE E1 in mice was observed to decrease airway eosinophil and lymphocyte recruitment, a specific Th2 cytokine, IL-13, ovalbumin-specific IgE, and AHR to inhaled methacholine [45]. RvE1 promoted the resolution of inflammatory airway responses in part by directly suppressing the production of IL-23 and IL-6, which promote the survival and differentiation of IL-17-producing T helper cells in the lung [ [58,59]. 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3) potentiates the efficacy of immunotherapy, and the regulatory cytokines IL-10 and TGF-beta play a crucial role in the effector phase of this mouse model [60].…”

Section: Effects On Inflammatory Cells and Cytokinesmentioning

confidence: 99%

Dietary or Supplementary Intake Modulates Inflammatory Response in Asthma Response in Asthma

Matsumura¹

2015

Glob J Allergy

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SummaryThe importance of diet and supplement intake in the onset and development of asthma has been advocated recently, and it may be important in the prevention and management of bronchial asthma. Long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs), vitamins (Vit), choline, and probiotics may be candidates to reduce medication use and provide some protection from risk. Experimental studies of diet in bronchial asthma have demonstrated modification of pulmonary function and the immune system through mechanisms involving antioxidant effect, T-helper (Th) 2 and Th17 inhibition, tolerogenic regulatory T cell (Treg) function promotion, nuclear transcription factors and epigenetic regulation. Although studies in animal models have provided evidence of supportive effects of diet in asthma, there have been few longitudinal studies of dietary or supplement intake and asthma, and the available epidemiological data remain controversial and inconclusive.prevalence of asthma and allergy in their offspring [20]. Cord serum 25-Hydroxyvitamin D level was inversely associated with the risk of transient early wheezing by the age of 5 years, but no association was found with asthma [21]. Recent published data demonstrated that Vit D3 did not reduce the rate of first treatment failure or exacerbation in adults with persistent asthma and Vit D insufficiency, suggesting that therapeutic Vit D3 supplementation in patients with symptomatic asthma was not useful [22].

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The vitamin D slant on allergy

Cited by 83 publications

References 107 publications

Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma

Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma

Food Allergy Prevention and Treatment by Targeted Nutrition

Dietary or Supplementary Intake Modulates Inflammatory Response in Asthma Response in Asthma

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