HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population

Douroudis, Konstantinos; Tarassi, Katerina; Athanassiades, Theofilos; Giannakopoulos, F.; Kominakis, A.; Thalassinos, Nikolaos; Papasteriades, C.

doi:10.1111/j.1399-0039.2007.00833.x

Cited by 10 publications

(11 citation statements)

References 32 publications

(27 reference statements)

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“…A study of postmenopausal women found an increased frequency of HLA-DR15 and -DQ6 supertypes in osteoporotic women compared to healthy controls [9]. The authors also report that a higher frequency of HLA-B07 was found in the osteoporotic group.…”

Section: Discussionmentioning

confidence: 88%

“…Osteoporosis has a strong genetic component [8], yet there are limited data regarding the influence of HLA polymorphisms on reduced bone mineral density (BMD) and osteoporosis. A study in postmenopausal women showed significant association between HLA alleles and bone loss, with increased frequency of HLA-DR15 ( P = .019) and -DQ6 (P = .026) supertypes in osteopenic and osteoporotic women compared with healthy controls [9]. HLA-B27 transgenic rats show increased levels of bone resorption markers and reduced BMD [10].…”

Section: Introductionmentioning

confidence: 99%

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HLA Alleles Association with Changes in Bone Mineral Density in HIV-1-Infected Adults Changing Treatment to Tenofovir-Emtricitabine or Abacavir-Lamivudine

et al. 2014

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BackgroundThere are limited data regarding the influence of human leukocyte antigen (HLA) polymorphisms on reduced bone mineral density (BMD). We investigated the relationship between HLA supertypes and BMD in HIV-infected adults changing their existing treatment to tenofovir-emtricitabine (TDF-FTC) or abacavir-lamivudine (ABC-3TC) in the STEAL study.MethodsLumbar spine and right hip BMD were measured by Dual-energy X-ray absorptiometry (DXA). HLA genotypes at the 2-digit level were classified into class I and II supertypes. Student's t-tests were used to test the association between HLA supertypes and changes in hip and spine BMD over 96 weeks for the whole cohort and stratified by randomised groups. The relationship between HLA supertypes and BMD was also assessed in the subgroup of participants that were naïve to both ABC and TDF at study entry.ResultsClass II supertypes were mainly associated with hip BMD change. Overall, compared to participants not carrying HLA-DQ3, participants expressing DQ3 had less bone loss over 96 weeks at both the hip and spine (hip: 0.003 vs. −0.006 g/cm2, 95%CI 0.002 to 0.017, p = 0.016; spine: 0.006 vs. −0.006 g/cm2, 95%CI 0.001 to 0.023, p = 0.041). In participants that were naïve to both ABC and TDF at baseline and randomised to TDF-FTC, DQ3 was significantly associated with less bone loss compared with those not carrying DQ3 (hip: 0.001 vs. −0.032 g/cm2; diff 0.033; 95%CI 0.017 to 0.049; p<0.001; spine: 0.007 vs. −0.023 g/cm2; diff 0.035; 95%CI 0.014 to 0.056; p = 0.001).ConclusionsIn this cohort of HIV-infected adults, there was an association between bone status and HLA supertypes, particularly HLA-DQ3.Trial RegistrationClinicaltrials.gov NCT00192634

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

HLA Alleles Association with Changes in Bone Mineral Density in HIV-1-Infected Adults Changing Treatment to Tenofovir-Emtricitabine or Abacavir-Lamivudine

et al. 2014

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“…Douroudis et al . () found that HLA‐B7, ‐DR15 and ‐DQ6 ( P = 0.026) were associated with a lower BMD measured at the forearm, and their study showed a significant association between HLA alleles and bone mass loss in the postmenopausal osteoporosis of Greek population. Due to the distributions of HLA alleles, haplotypes show high variation in different ethnic groups or even the same ethnic group living in different geographic areas (Zhou et al ., ).…”

Section: Introductionmentioning

confidence: 93%

Associations between polymorphisms of HLA‐B gene and postmenopausal osteoporosis in Chinese Han population

Zhou

Liu

2014

Int J Immunogenetics

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Osteoporosis is a systemic skeletal disease, which is more prevalent in postmenopausal women. Osteoporosis likely develops beginning with genetic risk. This study explored the relationships between polymorphisms of HLA-B gene and postmenopausal osteoporosis in a Chinese Han population. Polymerase chain reaction sequence-based typing (PCR-SBT) method was used for DNA typing at HLA-B locus in 70 patients with postmenopausal osteoporosis and 73 healthy controls in female Han population of Shaanxi Province, situated in north-western China. We found that 40 HLA-B alleles in postmenopausal osteoporosis patients and control subjects, respectively. Furthermore, the frequency of HLA-B* 3501 allele was significantly higher in postmenopausal osteoporosis patients than in the control group (P = 0.033), and the relative risk was 7.632 (95% CI: 0.927-62.850). Our results suggest that HLA-B* 3501 was likely an important risk factor for postmenopausal osteoporosis. As different populations have different HLA polymorphisms, further investigation of the relationship of various HLA genes and osteoporosis with larger sample size is still necessary in the future.

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“…They concluded that the HLA-A*24-B*07-DRB*01 haplotype might be a new genetic marker implicated with low PBM in healthy young Japanese women. In addition, Douroudis et al (2007) found that HLA-B7, -DR15, and -DQ6 (P = 0.026) were associated with a lower BMD measured at the forearm; their study showed a significant association between HLA alleles and bone mass loss in postmenopausal osteoporosis within the Greek population. However, to the best of our knowledge, there are few studies concerning the association of HLA gene polymorphisms and osteoporosis susceptibility in the Han Chinese population.…”

Section: Introductionmentioning

confidence: 96%

“…Furthermore, several studies have demonstrated strong associations between certain HLA alleles and osteoporosis susceptibility in the Japanese and Greek female populations (Tsuji et al, 1998;Douroudis et al, 2007). For instance, Tsuji et al (1998) investigated the association of HLA polymorphism with peak bone mass (PBM) in order to elucidate the genetic background of bone metabo-lism in young Japanese women.…”

Section: Introductionmentioning

confidence: 99%

HLA-A gene polymorphisms contribute to osteoporosis susceptibility in postmenopausal Han Chinese women

Yang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. Prompted by these findings, this study was designed to explore the associations between HLA-A gene polymorphisms and postmenopausal osteoporosis in the Han Chinese population. The polymerase chain reaction-sequence-based typing method was used for DNA genotyping at the HLA-A locus in 70 patients with postmenopausal osteoporosis and 73 healthy controls. We identified 17 HLA-A alleles in patients with postmenopausal osteoporosis and 20 HLA-A alleles in control subjects. Furthermore, we found that the frequency of the HLA-A* 02:07 allele was significantly higher in patients with postmenopausal osteoporosis than in control subjects (P = 0.023), and the relative risk was 4.065 (95% confidence interval = 1.109-14.893). Our study provides supportive evidence for the contribution of HLA-A gene polymorphisms to the susceptibility to postmenopausal osteoporosis and suggests that HLA-A* 02:07 is likely an important genetic risk factor for postmenopausal osteoporosis in the Han Chinese population.

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HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population

Cited by 10 publications

References 32 publications

HLA Alleles Association with Changes in Bone Mineral Density in HIV-1-Infected Adults Changing Treatment to Tenofovir-Emtricitabine or Abacavir-Lamivudine

HLA Alleles Association with Changes in Bone Mineral Density in HIV-1-Infected Adults Changing Treatment to Tenofovir-Emtricitabine or Abacavir-Lamivudine

Associations between polymorphisms of HLA‐B gene and postmenopausal osteoporosis in Chinese Han population

HLA-A gene polymorphisms contribute to osteoporosis susceptibility in postmenopausal Han Chinese women

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