Association of the <i>CT</i> gene (CA) polymorphism with BMD in osteoporotic mexican women

Magaña, Jonathan J.; Gómez, Rocío; Cisneros, Bulmaro; Casas, Leonora; Castorena‐Torres, Fabiola; Miranda, Agnese; Díez, Pilar; Castro, Clementina; Rubio, Julieta; Valdes, Mariana

doi:10.1111/j.1399-0004.2006.00703.x

Cited by 11 publications

(3 citation statements)

References 41 publications

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“…To genotype the TA repeat and the G2014A polymorphisms of the ERα gene, the Mexican population under study was classified into the osteoporotic group (70 osteoporotic women), the control group (70 non‐osteoporotic women) and the general population group (500 subjects). We previously reported the identification of Mexican osteoporotic and non‐osteoporotic women (7).…”

Section: Resultsmentioning

confidence: 99%

“…The general Mexican population sample was obtained from the blood reference Center of the Genomic Medicine Department of Biomedical Investigation Institute – UNAM, which recruited individuals from the different geographic zones of Mexico; therefore, our sample is a representative group of the Mexican population. The identification of Mexican osteoporotic and non‐osteoporotic women was previously reported by Magaña et al (7) following the criteria of the World Health Organization.…”

Section: Methodsmentioning

confidence: 99%

“…Given the complex structure of skeleton, it is likely that many skeletal genes are responsible for this genetic component. In fact, some studies have related bone metabolism with polymorphisms localized in or adjacent to different gene sequences, such as the vitamin D receptor gene (6), the calcitonin gene (7), the estrogen receptor alpha gene (ERα) (8), the estrogen receptor beta gene (ERβ) (9), and others (10–15).…”

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confidence: 99%

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Association of the estrogen receptor α gene polymorphisms with osteoporosis in the Mexican population

Gómez¹,

Magaña

Cisneros³

et al. 2007

Clinical Genetics

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The estrogen receptor gene (ER alpha) has been implicated in the development of osteoporosis. In this study, the association of two ER alpha gene polymorphic markers (a TA dinucleotide repeat and a single nucleotide polymorphism, G2014A) with osteoporosis was tested in 70 osteoporotic women, 70 non-osteoporotic women and 500 subjects from the Mexican population. According to the genetic analysis of the Mexican population using eight unlinked polymorphic markers, we found that our population is structured into three subpopulations; therefore, the allele-phenotype relationship was analyzed with a statistical method that considered population stratification. We found that the G2014A polymorphism is associated with the presence of osteoporosis while the TA dinucleotide repeat is not. The G allele and the GG genotype frequencies of the G2014A marker were significantly higher in osteoporotic than in non-osteoporotic women. Likewise, subjects bearing the G allele in heterozygous or homozygous displayed lower values for lumbar bone mineral density and T score than those who did not present any G allele. The effect of confounders for osteoporosis on the association of G allele-osteoporosis was ruled out. In summary, we conclude that the G2014 polymorphism may become a useful marker for genetic studies of osteoporosis in the Mexican population.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Association of the estrogen receptor α gene polymorphisms with osteoporosis in the Mexican population

Gómez¹,

Magaña

Cisneros³

et al. 2007

Clinical Genetics

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Association of IL-6 G-174C polymorphism with bone mineral density

Zhang

et al. 2013

J Bone Miner Metab

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Functional polymorphisms in the promoter region of interleukin-6 (IL-6) are known to be involved in bone mineral density (BMD) and the development of osteoporosis, but the reported results have been inconsistent. Using the meta-analysis approach, the present study is designed to provide a relatively comprehensive picture of the relationship between bone mineral density (BMD) or osteoporosis and polymorphisms in the promoter region of IL-6 (rs1800795 and rs1800796). The difference of bone mineral density (BMD) values between genotypes was examined by mean difference and 95 % confidence intervals (CIs). Association between IL-6 polymorphism and clinical osteoporosis was evaluated by pooled odds ratios (ORs) and 95 % CIs. A total of 13 articles with 11,499 subjects were included in the present study. For -174 (rs1800795), we found that individuals with the G/G genotype had a significantly lower BMD value than those with C/C genotype at femoral neck (0.02 g/cm(2), 95 % CI 0.00-0.03) (p = 0.04) and distal radius (0.01 g/cm(2), 95 %CI 0.01-0.01) (p < 0.0001). However, we did not find a statistically significant difference of BMD at the spine. When analysis was limited to postmenopausal women, similar results were obtained. We further found that the C/C genotype was associated with a reduced risk of osteoporosis compared to G/G genotype, and the pooled OR was 0.72 (95 % CI 0.54-0.95, p = 0.02). In addition, a significant relationship was found between G-634C (rs1800796) polymorphism and distal radius BMD (CC vs. GG: 0.02 g/cm(2), 95 % CI 0.01-0.03; GC vs. GG: 0.02 g/cm(2), 95 % CI 0.00-0.03) in the Asian population. These findings suggest that the CC genotype of IL-6 G-174C polymorphism may be associated with high BMD at femoral neck and distal radius and decreased risk of osteoporosis in the Caucasian population whereas G-634C polymorphism was associated with distal radius BMD in Asians.

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Association of LRP5 haplotypes with osteoporosis in Mexican women

et al. 2012

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Osteoporosis is a common health problem in Mexico, so it is essential to investigate the status of different gene polymorphisms that could serve as genetic susceptibility markers in the Mexican population. Genes with a role in bone metabolism are excellent candidates for association studies. In this study were determined the allelic and genotypic frequencies of four polymorphic markers (C/T rs3736228, G/A rs4988321, T/C rs627174 and T/C rs901824) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) and their association with osteoporosis in 100 pos-menopausal osteoporotic Mexican women and their controls, using real time-PCR and TaqMan probes. Only the G/A polymorphism (rs4988321, Val667Met) showed significant differences (p = 0.039) when genotype frequencies were compared. However, when the haplotypes of these four polymorphisms were analyzed, interesting associations became evident. The CGTT haplotype showed significant association with low risk of osteoporosis (OR 0.629; p = 0.007; [95 % CI, 0.448-0.884]), whereas the TACT haplotype was significantly associated with a higher risk of osteoporosis (OR 7.965; p = 0.006; [95 % CI, 1.557-54.775]). Our results supported the association of LRP5 with osteoporosis and showed the potential value of LRP5 haplotypes to identify risk of osteoporosis in Mexican population.

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Association of the CT gene (CA) polymorphism with BMD in osteoporotic mexican women

Cited by 11 publications

References 41 publications

Association of the estrogen receptor α gene polymorphisms with osteoporosis in the Mexican population

Association of the estrogen receptor α gene polymorphisms with osteoporosis in the Mexican population

Association of IL-6 G-174C polymorphism with bone mineral density

Association of LRP5 haplotypes with osteoporosis in Mexican women

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