2001
DOI: 10.1111/j.1365-2958.2001.02299.x
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Abstract: The volume of electron flow through the cbb3 branch of the electron transport chain and the redox state of the quinone pool generate signals that regulate photosynthesis gene expression in Rhodobacter sphaeroides. An inhibitory signal is generated at the level of the catalytic subunit of the cbb3 cytochrome c oxidase and is transduced through the membrane-localized PrrC polypeptide to the PrrBA two-component activation system, which controls the expression of most of the photosynthesis genes in response to O2.… Show more

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Cited by 98 publications
(39 citation statements)
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“…It has been known for several years that photosynthesis gene expression is elevated in the presence of oxygen in cells lacking a functional cbb 3 -type cytochrome c oxidase [81]. The working hypothesis to describe this observation suggested that the cbb 3 -type cytochrome c oxidase generates a signal that increases in magnitude with increasing electron flow through this enzyme [46,47]. This signal, in turn, results in the absence of the phosphorylated form of PrrA, namely PrrA~P, because the PrrB phosphatase activity is stimulated [76].…”
Section: System Ii: Regulation Mediated By Electron Flowmentioning
confidence: 94%
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“…It has been known for several years that photosynthesis gene expression is elevated in the presence of oxygen in cells lacking a functional cbb 3 -type cytochrome c oxidase [81]. The working hypothesis to describe this observation suggested that the cbb 3 -type cytochrome c oxidase generates a signal that increases in magnitude with increasing electron flow through this enzyme [46,47]. This signal, in turn, results in the absence of the phosphorylated form of PrrA, namely PrrA~P, because the PrrB phosphatase activity is stimulated [76].…”
Section: System Ii: Regulation Mediated By Electron Flowmentioning
confidence: 94%
“…If the AppA flavin can monitor quinone pool status, this would also couple both light and oxygen sensing. While details of the AppA photo-excitation process emerge [105], other features of this complex protein have yet to be examined, including a potential heme binding domain and an iron-sulfur center [47]. A possible role for the heme binding domain will be presented later.…”
Section: Milestone 2: Appa Is a Flavoprotein [102]mentioning
confidence: 99%
“…Instead, severely impaired magnetosome formation likely results from the loss of cbb 3 oxidase per se, which argues for a more direct role of this enzyme in magnetite biomineralization. In R. sphaeroides, besides its role as a terminal oxidase, cbb 3 also functions as a redox sensor to repress the activity of photosynthesis genes under aerobic conditions by controlling the activity of transcriptional regulators of photosynthesis gene expression (29)(30)(31)(32). Similarly, the cbb 3 oxidase of MSR-1 seems to share some functions with the periplasmic nitrate reductase Nap, one of the enzymes involved in poising the redox state for magnetite synthesis (6).…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, in the alphaproteobacterium Rhodobacter sphaeroides, it was shown previously that besides being a terminal oxidase, the cbb 3 oxidase also functions as an O 2 sensor to control the expression of photosynthesis genes (29)(30)(31)(32). Therefore, we hypothesized that cbb 3 oxidase of MSR-1 may also sense O 2 to simultaneously activate and balance denitrification and aerobic respiration and, thus, to maintain proper redox conditions for magnetite synthesis under microaerobic conditions.…”
Section: Identification Of Terminal Oxidases Involved In Aerobic Respmentioning
confidence: 99%
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