1990
DOI: 10.1111/j.1365-2133.1990.tb16121.x
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: In subjects older than 25-30 years the number of enzymatically active melanocytes detectable by the dopa reaction decreases by about 10-20% per decade, with exposed skin having approximately twice as many pigment cells as unexposed skin. Chronic exposure to sunlight may stimulate the epidermal melanocyte system rather than accelerating chronological ageing. The number of melanocytic naevi declines with age. Despite the decreased melanocyte density, photoaged skin has irregular pigmentation and, frequently, the… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
89
1
1

Year Published

2004
2004
2016
2016

Publication Types

Select...
5
4
1

Relationship

0
10

Authors

Journals

citations
Cited by 153 publications
(94 citation statements)
references
References 32 publications
3
89
1
1
Order By: Relevance
“…Aging is associated with a 10% -20% reduction of melaninproducing melanocytes per decade (Snell and Bischitz 1963;Szabo 1967;Gilchrest et al 1979;Ortonne 1990), although it is not clear whether this is caused by a net loss of melanocytes, a decrease in their activity, or both. As a result, skin pigmentation and reactive tanning after exposure to UV irradiation is reduced with age in sun-protected areas (Hawk 1990;Ortonne 1990;Shlivko et al 2013).…”
Section: Aging Of Skin Pigmentary Systemmentioning
confidence: 99%
“…Aging is associated with a 10% -20% reduction of melaninproducing melanocytes per decade (Snell and Bischitz 1963;Szabo 1967;Gilchrest et al 1979;Ortonne 1990), although it is not clear whether this is caused by a net loss of melanocytes, a decrease in their activity, or both. As a result, skin pigmentation and reactive tanning after exposure to UV irradiation is reduced with age in sun-protected areas (Hawk 1990;Ortonne 1990;Shlivko et al 2013).…”
Section: Aging Of Skin Pigmentary Systemmentioning
confidence: 99%
“…Lentigines solares (LS) (also termed age spots, sun spots and actinic lentigines) are circumscribed, pigmented macules, usually brown in color, that range in size from a few millimeters to a few centimeters in diameter and may coalesce into even more extended lesions [42]. They typically appear on sun-exposed areas of the skin such as the neck, face and forearms [43] and increase in number with age, affecting more than 90% of the Caucasian population older than 50 years [44]. LS result from increased amounts of melanin in the basal and suprabasal layers of the epidermis.…”
Section: Induction Of Hyperpigmentation -Specific Mechanismsmentioning
confidence: 99%
“…1,[27][28][29] Previously, we demonstrated that the simplest amino acid, glycine, inhibits spontaneous melanogenesis in B16F0 melanoma cells. 14) In that study, the inhibitory effect of glycine was similar to that of kojic acid, which is a typical tyrosinase inhibitor.…”
Section: Discussionmentioning
confidence: 99%