Psychosomatic Analysis of Atopic Dermatitis Using a Psychological Test

Arima, Masaru; Shimizu, Yoshinori; Sowa, Junko; Narita, Tomohiro; Nishi, Izumi; Iwata, Nakao; Ozaki, Norio; Hashimoto, Sunao; Matsunaga, Kayoko

doi:10.1111/j.1346-8138.2005.tb00738.x

Cited by 42 publications

(44 citation statements)

References 10 publications

(14 reference statements)

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“…Arima et al ( 18) reported that depression was observed more commonly in patients with AD than in healthy individuals. In our study, the BDI score, which displays the status of depression, was slightly higher in AD than in healthy individuals, and there was no statistical significance between AD and HCs.…”

Section: Discussionmentioning

confidence: 98%

Association of Stress with Symptoms of Atopic Dermatitis

Bae¹,

Park²,

Noh³

et al. 2010

Acta Derm Venerol

101

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Psychological stress and atopic dermatitis (AD) symptoms appear to form a vicious cycle. This study compared the degree of stress and impairment of dermatology life quality between patients with AD and healthy controls, and examined for neuropeptides and neurotrophins associated with stress in AD. Questionnaires, comprising five tests evaluating depression, anxiety, interaction anxiousness, private body consciousness, and dermatology life quality, were examined in age- and sex-matched patients with AD (n = 28) and healthy controls (n = 28). Immunohistochemical staining of nerve growth factor, substance P, corticotrophin-releasing factor receptor and neuropeptide Y was performed in the AD-involved and normal skin. Patients with AD showed high scores on all of the questionnaires, including Beck Depression Inventory, state anxiety, trait anxiety, Interaction Anxiousness Scale, Private Body Consciousness subscale, and Dermatology Life Quality Index. All of the parameters, except for Beck Depression Inventory, showed higher values in AD than healthy controls (p < 0.001). Statistically significant correlations were observed between each psychological parameter and Dermatology Life Quality Index. Among the clinical parameters, only pruritus was positively correlated with state anxiety (R = 0.573, p < 0.05) and trait anxiety (R = 0.525, p < 0.05). The Eczema Area and Severity Index score did not show any significant correlations with psychological parameters. Nerve growth factor-reactive cells were observed more abundantly and intensely in both epidermis and dermis of AD involved skin (n = 4) than in healthy controls (n = 3) (p = 0.022 and 0.029, respectively). Also, the number and intensity of neuropeptide Y-positive cells was significantly greater in the entire epidermis of patients with AD than in healthy controls (n = 3) (p = 0.029 and 0.026, respectively). We conclude that anxiety may be associated with the induction of pruritus through neuro-peptide Y and nerve growth factor.

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Section: Discussionmentioning

confidence: 98%

Association of Stress with Symptoms of Atopic Dermatitis

Bae¹,

Park²,

Noh³

et al. 2010

Acta Derm Venerol

101

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“…Dermatologists have found a correlation between the severity of atopic dermatitis and the level of patients' depression or anxiety (11,12). Sleep disturbance due to itching and concern over appearance might be associated with depression and anxiety.…”

Section: Discussionmentioning

confidence: 99%

Low environmental humidity induces synthesis and release of cortisol in an epidermal organotypic culture system

Takei

Denda

Kumamoto

et al. 2013

Experimental Dermatology

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Dry environmental conditions induce a variety of skin pathologies and a recent report indicating that cortisol synthesis in epidermis was increased during wound healing led us to hypothesize that environmental dryness might induce increased cortisol secretion in epidermis. Therefore, we incubated a skin equivalent model under dry (relative humidity: less than 10%) and humid (relative humidity: approximately 100%) conditions for 48 hours and evaluated cortisol secretion and mRNA levels of cortisol-synthesizing enzyme (steroid 11b-hydroxylase, CYP11B1) and IL-1b. Cortisol secretion was increased threefold, and CYP11B1 and IL-1b mRNAs were increased 38-fold and sixfold, respectively, in the dry condition versus the humid condition.Occlusion with a water-impermeable plastic membrane partially blocked the increases in cortisol secretion and CYP11B1 and IL-1b mRNA expression in the dry condition. Thus, environmental dryness might induce increased cortisol secretion in epidermis of diseased skin characterized by epidermal barrier dysfunction, potentially influencing mental state and systemic physiology.Abbreviations: CYP, cytochrome P450; CYP11B1, steroid 11b-hydroxylase (cortisol-synthesizing enzyme); IL-1b, interleukin 1 beta.

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“…It has been reported that the stress after the Hanshin Awaji earthquake disaster in Japan influenced the symptoms of AD, suggesting that natural disasters affect AD symptoms [2]. Furthermore, exacerbation of AD symptoms has been seen in patients under the influence of stress [3, 4], thus implying the fact that emotional factors contribute to the severity of AD. …”

Section: Introductionmentioning

confidence: 99%

Stress Evaluation in Adult Patients with Atopic Dermatitis Using Salivary Cortisol

Mizawa

Ueda

Makino

et al. 2013

BioMed Research International

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The symptoms of atopic dermatitis (AD) are often aggravated by stress, and AD can also lead to psychological stress due to social isolation and discrimination. The salivary cortisol level reflects psychological stress, and it is a good index to assess chronic stress. In this study, we measured the salivary cortisol levels in patients with AD (n = 30) and compared them with those of healthy control subjects (n = 42). AD patients were also evaluated for general disease severity using the Scoring Atopic Dermatitis (SCORAD) index. The serum levels of TARC, total IgE, and lactate dehydrogenase (LDH) and peripheral blood eosinophil counts were measured by laboratory tests. The Skindex-16 was used as a skin disease-specific, quality of life measure, instrument. The results showed that the saliva cortisol level was significantly higher in AD patients compared to healthy subjects (P < 0.01). The salivary cortisol level was significantly correlated with the SCORAD index (r = 0.42, P < 0.05) while the serum TARC and LDH levels were positively correlated with the SCORAD index. However, no statistically significant correlations were observed between the salivary cortisol level and Skindex-16. These results suggest that the saliva cortisol level is therefore a useful biomarker to evaluate the stress in AD patients.

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Psychosomatic Analysis of Atopic Dermatitis Using a Psychological Test

Cited by 42 publications

References 10 publications

Association of Stress with Symptoms of Atopic Dermatitis

Association of Stress with Symptoms of Atopic Dermatitis

Low environmental humidity induces synthesis and release of cortisol in an epidermal organotypic culture system

Stress Evaluation in Adult Patients with Atopic Dermatitis Using Salivary Cortisol

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