2007
DOI: 10.1109/tnb.2007.908987
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Abstract: In this work, we present a short summary of the synthesis and characterization of superparamagnetic iron oxide nanoparticles and their behavior in vitro and in vivo. Therefore, we have used various characterization techniques to deduce the physical particle size as well as magnetic properties. It is shown that the particle properties were significantly improved by a thermochemical treatment and dialysis, obtaining weakly interacting particles with a clear blocking temperature. We also present the interaction o… Show more

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Cited by 72 publications
(53 citation statements)
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“…First of all, the magnetic properties of SPIONs are very interesting to increase the cellular uptake rate of these nanoparticles with a magnet [22] and then to improve the labeling of cells for biomedical applications [23,24]. The concentration and the charge play a significant role in the cellular internalization [25].…”
Section: Cellular Uptake and Biodistribution Of Superparamagnetic Iromentioning
confidence: 99%
“…First of all, the magnetic properties of SPIONs are very interesting to increase the cellular uptake rate of these nanoparticles with a magnet [22] and then to improve the labeling of cells for biomedical applications [23,24]. The concentration and the charge play a significant role in the cellular internalization [25].…”
Section: Cellular Uptake and Biodistribution Of Superparamagnetic Iromentioning
confidence: 99%
“…Although they provide less contrast enhancement per particle compared with SSPIO and MPIO, large numbers of particles can be loaded into each cell [18,19]. As cationic surfaces have been shown to facilitate cellular internalization [20,21], USPIO are often modified with polycationic cell permeating peptides (CPP) such as HIV transactivator (TAT) [22] or protamine [23]. Other transfection techniques, sometimes in concert with CPPs, are also used [24,25].…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, selected small functional iron oxide NPs (in the size range of 5-30 nm) are now commercially available and FDA-approved [6] for clinical use (mainly MRI). In this context, numerous in vitro toxicity studies concerning different iron oxide particles functionalized by a great variety of polymers [7,8] such as polyethylene imine (PEI) [9] PVA (polyvinyl alcohol), PLL (poly-L-lysine), PDMA (poly N,Ndimethylacrylamide) and PEGs (polyethylene glycols) [10] have recently been reviewed, showing the major importance of correctly designed NPs surface engineering.…”
Section: Introductionmentioning
confidence: 99%