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Cited by 413 publications
(291 citation statements)
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References 56 publications
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“…Deletion of both α and β TRs is compatible with life [36,37]. This contrasts with the complete TH deficiency in the athyreotic Pax8KO mouse that dies prior to weaning, unless rescued by TH.…”
Section: Combined Tr and Related Gene Deletionsmentioning
confidence: 66%
“…Deletion of both α and β TRs is compatible with life [36,37]. This contrasts with the complete TH deficiency in the athyreotic Pax8KO mouse that dies prior to weaning, unless rescued by TH.…”
Section: Combined Tr and Related Gene Deletionsmentioning
confidence: 66%
“…Thra/Thrb double-knockout mice have also been generated and, surprisingly, survive, showing that the presence of Trs is not essential for viability (Gauthier et al, 1999;Gothe et al, 1999). Although these mice show extreme Th resistance, they do not display the severe, lethal phenotype seen in mice that are congenitally deficient for Th (Flamant et al, 2002).…”
Section: Introductionmentioning
confidence: 98%
“…The respective roles of TR␣1 and TR␤1, their target genes, and the downstream molecular events that account for T3-increased microglial survival or process growth remain to be clarified. The study of mice deficient for TR␣, TR␤, or both types of receptors (Göthe et al, 1999) should help answer this question. Interestingly, Arpin et al (2000) showed that 17-dold TR␣-deficient mice had reduced numbers of splenic macrophages compared with wild-type littermates.…”
Section: Pathways For Thyroid Hormone Influences On Microglia: Assessmentioning
confidence: 99%