“…Lung‐on‐a‐chip models have recently received great attention as they can mimic the 3D microarchitecture and microenvironment, breathing movements as well as primary physiological functions of the human lung (Gkatzis et al, 2018; Huh et al, 2010; Huh, 2015; Li et al, 2019). Although lung‐on‐a‐chip models are not directly translatable to clinical applications, they are considered a useful tool to help lung tissue engineering and regenerative medicine (Leiby et al, 2020) by serving as a small‐scale bioreactor to perform lung physiological studies (Huh et al, 2010; Sellgren et al, 2014; Stucki et al, 2015; Zamprogno et al, 2019), disease modeling (Benam et al, 2016; Felder et al, 2014, 2019; Hassell et al, 2017; Huh et al, 2010, 2012; Jain et al, 2018; Nesmith et al, 2014; Stucki et al, 2015; Xu et al, 2013; Yang et al, 2018), toxicological studies (Huh et al, 2010; Zhang et al, 2018), and drug development (Benam et al, 2016; Huh et al, 2012; Jain et al, 2018; Xu et al, 2013).…”