“…Tricyclic antidepressants, having very potent antihistaminic and anticholinergic effects, can interfere with cognitive and psychomotor functions [Riedel and van Praag, 1995]. Sertraline, however, has been shown to have no adverse effect on cognition in healthy volunteers [Furlan et al, 2001;Schmitt et al, 2002]. As our study shows an adverse effect on the executive functions of inhibition in depressed subjects, an improvement in these functions during sertraline treatment was probably related to the reduction in blood flow and cerebral glucose metabolism in the frontal regions in the depressive state [Baxter et al, 1989, Bench et al, 1992, Martinot et al, 1990 and to the increase in cerebral glucose metabolism in the frontal regions after 10 weeks of sertraline treatment [Buchsbaum et al, 1997].…”