2009
DOI: 10.1095/biolreprod.108.073833
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Abstract: Chlamydia trachomatis is a common sexually transmitted bacterial infection that results in health care costs in the United States that exceed $2 billion per year. Chlamydia infections cause damage to the oviducts, resulting in ectopic pregnancy and tubal factor infertility, but the reasons for defective oviduct function are poorly understood. We have investigated the role of oviduct contractions in egg transport and found that underlying electrical pacemaker activity is responsible for oviduct motility and egg… Show more

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Cited by 78 publications
(75 citation statements)
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“…This will eventually lead to permanent tubal tissue damage and scaring [114]. Chlamydial infection can affect oviductal smooth muscle and destroy its spontaneous contractile activity which will ultimately result in stasis and retention of the oviduct secretions, hydro/ pyosalpinx formation and infertility [115].…”
Section: Smokingmentioning
confidence: 99%
“…This will eventually lead to permanent tubal tissue damage and scaring [114]. Chlamydial infection can affect oviductal smooth muscle and destroy its spontaneous contractile activity which will ultimately result in stasis and retention of the oviduct secretions, hydro/ pyosalpinx formation and infertility [115].…”
Section: Smokingmentioning
confidence: 99%
“…Chlamydia infection thus has been used in mice to develop a model system for ectopic pregnancy. In this model, the muscle tone of the oviductal wall is attenuated and the electrical pacemaker potential required for oviductal motility is lost (116,118). Thus, tubal infections increase the chance of ectopic pregnancy by delaying oviductal embryo transport.…”
Section: Pregnancy Loss: Wrong Place Wrong Timingmentioning
confidence: 99%
“…Studies in the murine model have demonstrated that interstitial cells of Cajal (ICC), which form a dense network associated with the smooth muscle cells of the oviduct, are the source of the electrical pacemaker activity responsible for oviduct motility and egg transport, and that these cells are damaged by the inflammatory responses released by chlamydia infection. The destruction of the oviduct ICC networks might contribute to oviduct stasis and pseudo-obstruction, functional block of oocyte transport and retention of secretions, which could progress to fibrosis, tubal occlusion and finally infertility (32). Hydrosalpinx, a result of tubal obstruction, is present in about 30% of women with tubal factor infertility (TFI), and the fluid can reflux into the uterine cavity, inhibiting implantation of embryos in the endometrium.…”
Section: Tubal Factor Infertilitymentioning
confidence: 99%