2007
DOI: 10.1093/toxsci/kfm074
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Abstract: Topical exposure to nanoscale materials is likely from a variety of sources including sunscreens and cosmetics. Because the in vivo disposition of nanoscale materials is not well understood, we have evaluated the distribution of quantum dots (QDs) following intradermal injection into female SKH-1 hairless mice as a model system for determining tissue localization following intradermal infiltration. The QD (CdSe core, CdS capped, poly[ethylene glycol] coated, 37 nm diameter, 621 nm fluorescence emission) were i… Show more

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Cited by 156 publications
(121 citation statements)
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References 49 publications
(65 reference statements)
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“…In support of this hypothesis, studies have shown that after subcutaneous QD injection, some nanomaterials end up in draining lymph nodes. 33 Solid lipid nanoparticles designed for magnetic resonance imaging have been shown to enter lymph after duodenal administration to rats. 34 In other imaging studies conducted in pigs, intradermal injection of 400 pMoles of fluorescent QD targeted sentinel lymph nodes, 35 a finding relevant to dermal absorption of even minute fractions of topically applied or orally dosed nanomaterials.…”
Section: Lymphatic Transportmentioning
confidence: 99%
“…In support of this hypothesis, studies have shown that after subcutaneous QD injection, some nanomaterials end up in draining lymph nodes. 33 Solid lipid nanoparticles designed for magnetic resonance imaging have been shown to enter lymph after duodenal administration to rats. 34 In other imaging studies conducted in pigs, intradermal injection of 400 pMoles of fluorescent QD targeted sentinel lymph nodes, 35 a finding relevant to dermal absorption of even minute fractions of topically applied or orally dosed nanomaterials.…”
Section: Lymphatic Transportmentioning
confidence: 99%
“…6,8 While ongoing toxicity and clearance studies remain to establish their clinical utility in humans, 13,14 their excellent intrinsic optical reporter properties have made them an indispensable tool in preclinical biology. This is true particularly for our application of the qdot as a model nanoparticle (for nanoparticles of comparable size and shape) to study the binding and extravasation parameters of targeted nanoparticles in tumor neovasculature.…”
mentioning
confidence: 99%
“…10 However, the monitoring time was limited to 1 h because of the loss of signal intensity at the injection site. Studies conducted by Gopee and coauthors 14 with intradermally injected quantum dots found that quantum dots migrated from the site of injection, with 60% of quantum dots remaining at the injection site after 24 h. Our nanosensors were implanted similarly in the skin, and migration was assumed to be the main cause of signal loss over time. To mitigate sensor migration in our system, sensor geometry was altered into microworms that limited sensor diffusion and prolonged their lifetime in the skin more than the nanosensors alone.…”
Section: Introductionmentioning
confidence: 88%