2021
DOI: 10.1093/nar/gkab1037
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Abstract: Since 2005, the Pathogen–Host Interactions Database (PHI-base) has manually curated experimentally verified pathogenicity, virulence and effector genes from fungal, bacterial and protist pathogens, which infect animal, plant, fish, insect and/or fungal hosts. PHI-base (www.phi-base.org) is devoted to the identification and presentation of phenotype information on pathogenicity and effector genes and their host interactions. Specific gene alterations that did not alter the in host interaction phenotype are also… Show more

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Cited by 55 publications
(18 citation statements)
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“…Three notable databases focus on host-pathogen interactions. The well-known PHI-BASE reports ( 62 ) new pathogens and hosts, and describes the range of other databases to which it contributes annotations. The second, VEuPathDB ( 63 ), is a new name to the Issue but contains genomic and a wide variety of other information on eukaryotic pathogens, their vectors and host, information previously stored in its parent databases VectorBase ( 64 ) and EuPathDB ( 65 ), each published here.…”
Section: New and Updated Databasesmentioning
confidence: 99%
“…Three notable databases focus on host-pathogen interactions. The well-known PHI-BASE reports ( 62 ) new pathogens and hosts, and describes the range of other databases to which it contributes annotations. The second, VEuPathDB ( 63 ), is a new name to the Issue but contains genomic and a wide variety of other information on eukaryotic pathogens, their vectors and host, information previously stored in its parent databases VectorBase ( 64 ) and EuPathDB ( 65 ), each published here.…”
Section: New and Updated Databasesmentioning
confidence: 99%
“…Predicted genes from each genome were BLAST searched against 7544 protein sequences in PHI-base (Pathogen–Host Interactions database, Version 4.1.3, , accessed 28 June 2022; [ 34 , 60 , 85 , 86 , 87 , 88 , 89 ]. Genes with significant hits (≤1 × 10 −5 and bit score ≥ 100) against PHI were considered pathogenicity-related genes.…”
Section: Methodsmentioning
confidence: 99%
“…Some of the avirulence genes ( AvrSr27 ) that aid in the resistance gene interactions (Sr27 - AvrSr27 ) with the host often contain secreted proteins from the invading host pathogen [ 33 ]. A catalogue of the all the tested pathogenicity proteins is indexed at pathogen–host interactions database [ 34 ].…”
Section: Introductionmentioning
confidence: 99%
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“…The Pathogen Host Interactions Database (PHI-base) has manually curated experimentally verified pathogenicity, virulence and effector genes from fungal, bacterial and protist pathogens [22]. The amino acid sequence of the target species of strain R1 was compared with the PHI database by using the BLAST software, and the gene of the target species was combined with the functional annotation information to obtain an annotation result.…”
Section: Additional Annotation 241 Pathogen Host Interactions (Phi)mentioning
confidence: 99%