2012
DOI: 10.1093/infdis/jir822
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Abstract: Among African American women with PID, variants in the TLR1 and TLR4 genes, which may increase signaling, were associated with increased C. trachomatis infection.

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Cited by 61 publications
(64 citation statements)
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References 40 publications
(60 reference statements)
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“…The haplotype, consisting of two distinct single nucleotide polymorphisms (SNPs), was found to be present in a significantly higher proportion of women with a history of Chlamydia infection who did not have tubal pathology and in sexual health clinic attendees and was present in a higher proportion of women who were asymptomatic (111). In the PEACH PID study TLR1 and TLR4 polymorphisms were found to be significantly associated with chlamydial PID (112), while SNPs from TLR2 (SNPs different from those included in the study of Karimi et al), TLR6, Myd88, and TIRAP were not significantly associated with chlamydial PID (112).…”
Section: Human Genotypic Factors Associated With C Trachomatis Infermentioning
confidence: 99%
“…The haplotype, consisting of two distinct single nucleotide polymorphisms (SNPs), was found to be present in a significantly higher proportion of women with a history of Chlamydia infection who did not have tubal pathology and in sexual health clinic attendees and was present in a higher proportion of women who were asymptomatic (111). In the PEACH PID study TLR1 and TLR4 polymorphisms were found to be significantly associated with chlamydial PID (112), while SNPs from TLR2 (SNPs different from those included in the study of Karimi et al), TLR6, Myd88, and TIRAP were not significantly associated with chlamydial PID (112).…”
Section: Human Genotypic Factors Associated With C Trachomatis Infermentioning
confidence: 99%
“…The prevention and treatment of PID is clearly complex, and more research is certainly needed to verify the actual effectiveness of chlamydia screening and PID diagnosis, as well as management, in the light of complexities of STD organisms, difficulties in interpreting conflicting studies, and challenges in reaching high-risk populations [71,85]. We should not reduce what is known to help prevent and manage PID in youth while searching for more data and cost-effective resources that will help reduce the complex challenge of STDs in youth.…”
Section: Resultsmentioning
confidence: 99%
“…For example, more research is needed on chlamydial innate immune response and PID development that is related to variants in Tolllike receptor 1 and 4 genes [71]. Other preventive strategies include the testing of high-risk men and the development of an effective vaccine for C. trachomatis and N. gonorrhoeae [14 & , 62,72].…”
Section: Preventionmentioning
confidence: 99%
“…Laisk et al [21] also investigated the role of this SNP in developing tubal pathology; they did not find any association. Taylor et al [23] studied a different TLR4 polymorphism, rs1927911, and found that the mutant genotype increases the susceptibility to C. trachomatis infections. Similarly, they found that the TLR1 rs5743618 TT genotype increased susceptibility to Chlamydia infections [23].…”
Section: Pattern Recognition Receptorsmentioning
confidence: 99%