Cohort Profile: The Barwon Infant Study

Vuillermin, Peter; Saffery, Richard; Allen, Katrina J.; Carlin, John B.; Tang, Mimi L.K.; Ranganathan, Sarath; Burgner, David; Dwyer, Terry; Collier, Fiona; Jachno, Kim; Sly, Peter D.; Symeonides, Christos; McCloskey, Kathleen G.; Molloy, John; Forrester, Michael A.; Ponsonby, Anne–Louise

doi:10.1093/ije/dyv026

Cited by 101 publications

(124 citation statements)

References 54 publications

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“…The Barwon Infant Study is a birth cohort study ( n = 1074) conducted in south‐eastern Australia (Appendix S1, Supporting Information). Ethics approval for this study was obtained from the Barwon Health Human Research Ethics committee, HREC number 10/24.…”

Section: Methodsmentioning

confidence: 99%

High incidence of respiratory disease in Australian infants despite low rate of maternal cigarette smoking

Gray

Ponsonby

Lin

et al. 2019

J Paediatrics Child Health

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Aim The burden of wheezing illnesses in Australian infants has not been documented since the success of initiatives to reduce maternal cigarette smoking. We aimed to determine the incidence of wheeze and related health‐care utilisation during the first year of life among a contemporary Australian birth cohort. Methods A birth cohort of 1074 infants was assembled between 2010 and 2013. Parents completed questionnaires periodically. Several non‐exclusive infant respiratory disease phenotypes were defined, including any wheeze, wheeze with shortness of breath and recurrent wheeze. Skin prick testing was performed to determine atopic wheeze. Health‐care utilisation for respiratory disease was determined from questionnaires and hospital medical records. Results Retention to 1 year was 840/1074 (83%). The incidence of any wheeze was 51.8% (95% confidence interval (CI) 48.3–55.2%), wheeze with shortness of breath 20.6% (95% CI 17.9–23.5), recurrent wheeze 19.4% (95% CI 16.8–22.2) and atopic wheeze 6% (95% CI 4.6–7.8). Respiratory illness resulted in primary health‐care utilisation in 82.2% (95% CI 79.3–84.8) of participants and hospital presentation in 8.8% (95% CI 7.2–10.6). Maternal smoking during pregnancy was uncommon (15.7%) and was not associated with wheeze or health resource utilisation. Male gender, familial atopy and asthma and smaller household size were associated with a higher incidence of wheeze. Conclusions The incidence of wheezing illness among Australian infants remains high despite relatively low rates of maternal smoking during pregnancy. The majority of the health‐care burden is borne by primary health‐care services. Further research is required to inform novel prevention strategies.

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Section: Methodsmentioning

confidence: 99%

High incidence of respiratory disease in Australian infants despite low rate of maternal cigarette smoking

Gray

Ponsonby

Lin

et al. 2019

J Paediatrics Child Health

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“…The BIS is a largely Caucasian birth cohort (n = 1,074 motherinfant pairs) from the Barwon region of south-eastern Australia [5]. Women were recruited prior to 28 weeks of pregnancy.…”

Section: The Barwon Infant Studymentioning

confidence: 99%

“…Women were recruited prior to 28 weeks of pregnancy. Infants were excluded if they were born prior to 32 completed weeks, developed a serious illness in the first week of life, or had significant congenital or genetic abnormalities [5]. Ethics approval for this study was granted by the Barwon Health Human Research and Ethics Committee (HREC 10/24).…”

Section: The Barwon Infant Studymentioning

confidence: 99%

“…Data on maternal age, parity, prenatal weight, and antenatal comorbidities were collected from questionnaires and hospital records, and by standardized clinical examination, and umbilical cord blood was collected at birth and placed in a serum clotting tube [5]. Cord blood samples were centrifuged within 2 h of collection and the serum was removed and stored at -80 ° C.…”

Section: The Barwon Infant Studymentioning

confidence: 99%

“…Further, we sought a priori to contextualize the findings by comparing them to a well-characterized lipidomic profile in a cohort with known clinical implications -the overweight and obese adult population. We used perinatal data and biological samples from the Barwon Infant Study (BIS) [5] in conjunction with the San Antonio Family Heart Study (SAFHS) [3].…”

Section: Introductionmentioning

confidence: 99%

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Gestational Age and the Cord Blood Lipidomic Profile in Late Preterm and Term Infants

McCloskey¹,

Livera

Collier³

et al. 2018

Neonatology

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Background: Lipid metabolism is vital to fetal development and cardiometabolic health and the final weeks of gestation are known to be a time of intense metabolic activity. New techniques such as lipidomics allow investigation of a complex lipidomic profile in infants. Objectives: This research aimed to (1) describe variations in lipidomic profile in late preterm and term infants and (2) compare variations to an adult lipidomic profile with known clinical implications. Methods: The Barwon Infant Study (n = 1,074) is a population-derived pre-birth cohort study. The lipidomic profile of cord blood was measured by liquid chromatography-mass spectrometry in 225 participants and the association between gestational age and lipidomic profile was investigated using multiple linear regression adjusting for birth weight, exposure to labour, and infant sex. Patterns of association with gestational age across the lipidomic profile were compared with associations between body mass index (BMI) and lipidomic profile observed among adults in the San Antonia Family Heart Study (n = 994). Results: Gestational age was independently associated with the abundances of 39% of lipid species. Variations in the lipidomic profile with increasing gestational age were comparable to some variations observed in association with increasing BMI among adults. Conclusion: There is a strong relationship between gestational age and the cord blood lipid profile at birth, providing further evidence for the importance of metabolic changes of late gestation. A number of the variations in the lipid profile with increasing gestational age are analogous to differences observed in the adult lipid profile with an increasing BMI.

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