1995
DOI: 10.1093/hmg/4.4.751
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Abstract: Genes in the 16.6 kb human mitochondrial DNA (mtDNA) are concerned exclusively with bioenergy production. Mutations in mtDNA can, therefore, lead to bioenergy decline and so contribute to various age-related degenerative diseases and even to 'natural' ageing (1-3). Large deletions in mtDNA occur in tissues of patients with mitochondrial myopathies and also occur in normal ageing, particularly in postmitotic tissues characterised by high energy demands and low rates of cell division, notably skeletal muscle, ca… Show more

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Cited by 42 publications
(17 citation statements)
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“…The latter may cause mutagenic mtDNA lesions and accumulations of these lesions [19]. ME/CFS has been shown to be accompanied by mitochondrial damage [10,11,20,21] and mitochondrial dysfunctions and structural changes [22,23], which is important in that these mitochondrial and mtDNA lesions may cause lowered activity of the mitochondrial respiratory chain, which produces ATP and accounts for 98% of cellular energy [19]. …”
Section: Backgroiundmentioning
confidence: 99%
“…The latter may cause mutagenic mtDNA lesions and accumulations of these lesions [19]. ME/CFS has been shown to be accompanied by mitochondrial damage [10,11,20,21] and mitochondrial dysfunctions and structural changes [22,23], which is important in that these mitochondrial and mtDNA lesions may cause lowered activity of the mitochondrial respiratory chain, which produces ATP and accounts for 98% of cellular energy [19]. …”
Section: Backgroiundmentioning
confidence: 99%
“…Furthermore, secondary structure motifs may also represent essential signals for the initiation of the replication of animal mtDNAs (Zhang et al, 1995: Comandi et al, 2009. In this respect, the A+T-rich region of both F. griesea specimens has the potential to fold in several paired structures (Fig.…”
Section: The Putative A+t-rich Region and Other Non-coding Regionsmentioning
confidence: 99%
“…Most of the deletions identified appear to be novel although one of these (Fig. 2A(ii)) was found to have been described previously in skeletal muscle (Zhang et al, 1995). The deletion shown in figure 2A(iii) may have been generated via cleavage at the 5′ end of one of two imperfect heptameric direct repeats but could also have been formed by cleavage sites at sites within the repeats.…”
Section: Resultsmentioning
confidence: 56%
“…This mechanism has been proposed to explain why, in certain mitochondrial disease states, unique mitochondrial mutations predominate in a large proportion of the cells of the affected tissues. From this standpoint it is noteworthy that one of the deletions uncovered in our screen was previously shown to be associated with chronic muscle fatigue syndrome (Zhang et al, 1995). This raises the possibility that many deletions of potential significance may not be detected in studies that rely on single amplimer pairs that target specific deletions.…”
Section: Discussionmentioning
confidence: 86%