2018
DOI: 10.1093/cercor/bhy072
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Abstract: The Kv3.1b potassium channel subunit is associated with narrow spike widths and fast-spiking properties. In macaque primary visual cortex (V1), subsets of neurons have previously been found to be Kv3.1b-immunoreactive (ir) but not parvalbumin (PV)-ir or not GABA-ir, suggesting that they may be both fast-spiking and excitatory. This population includes Meynert cells, the large layer 5/6 pyramidal neurons that are also labeled by the neurofilament antibody SMI-32. In the present study, triple immunofluorescence … Show more

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Cited by 14 publications
(13 citation statements)
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“…In rodents, the Kv3.1b channel is not expressed in excitatory neurons in cortex. However, it is expressed in some excitatory neurons in primate cortex (Constantinople et al, 2009;Kelly et al, 2019), and it is clearly expressed in the large Meynert cells located near the layer 5/6 border in monkey visual cortex (Ichinohe et al, 2004;Constantinople et al, 2009;Kelly et al, 2019). It is tempting to speculate that some of the high firing rate neurons in C1 are large pyramidal neurons that express Kv3.1b.…”
Section: Properties and Possible Functions Of Neurons In Different Lamentioning
confidence: 99%
“…In rodents, the Kv3.1b channel is not expressed in excitatory neurons in cortex. However, it is expressed in some excitatory neurons in primate cortex (Constantinople et al, 2009;Kelly et al, 2019), and it is clearly expressed in the large Meynert cells located near the layer 5/6 border in monkey visual cortex (Ichinohe et al, 2004;Constantinople et al, 2009;Kelly et al, 2019). It is tempting to speculate that some of the high firing rate neurons in C1 are large pyramidal neurons that express Kv3.1b.…”
Section: Properties and Possible Functions Of Neurons In Different Lamentioning
confidence: 99%
“…Identification of inhibitory and excitatory neurons in vivo has been challenging in monkeys. The discovery of fast-spiking excitatory neurons in primates undermines the use of extracellularly recorded spike waveforms ( Kelly et al, 2019 ). Optogenetic phototagging of inhibitory neurons, using AAV–mDlx5/6–ChR2 permits electrophysiological identification of neuronal subtypes more decisively ( Figure 9 ).…”
Section: Discussionmentioning
confidence: 99%
“…In rodents the Kv3.1b channel is not expressed in excitatory neurons in cortex. However, it is expressed in some excitatory neurons in primate cortex (Constantinople et al, 2009;Kelly et al, 2018), and it is clearly expressed in the large Meynert cells located near the layer 5/6 border in monkey visual cortex (Ichinohe et al, 2004;Constantinople et al, 2009;Kelly et al, 2018). It is tempting to speculate that some of the high firing rate neurons in C1 are large pyramidal neurons that express Kv3.1b.…”
Section: Properties and Possible Functions Of Neurons In Different Lamentioning
confidence: 99%