1998
DOI: 10.1093/brain/121.3.409
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Abstract: A key issue in developmental neuroscience is the role of activity-dependent mechanisms in the epigenetic induction of functional organization in visual cortex. Ocular blindness and ensuing visual deprivation is one of the rare models available for the investigation of experience-dependent cortical reorganization in man. In a PET study we demonstrate that congenitally blind subjects show task-specific activation of extrastriate visual areas and parietal association areas during Braille reading, compared with au… Show more

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Cited by 398 publications
(273 citation statements)
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“…images represented in 'the mind's eye' for sighted people (for reviews see for example Kosslyn et al 2001;Kosslyn and Thompson 2003), and similar arguments have been made for CC activity in blind people (e.g. Büchel et al 1998;Lambert et al 2004). A study by Cui et al (2007) found a significant positive correlation between sighted people's level of activation in the CC during visual imagery and their scores on a questionnaire that measures the vividness of their visual imagery (vividness of visual imagery questionnaire, VVIQ, Marks, 1973).…”
mentioning
confidence: 69%
“…images represented in 'the mind's eye' for sighted people (for reviews see for example Kosslyn et al 2001;Kosslyn and Thompson 2003), and similar arguments have been made for CC activity in blind people (e.g. Büchel et al 1998;Lambert et al 2004). A study by Cui et al (2007) found a significant positive correlation between sighted people's level of activation in the CC during visual imagery and their scores on a questionnaire that measures the vividness of their visual imagery (vividness of visual imagery questionnaire, VVIQ, Marks, 1973).…”
mentioning
confidence: 69%
“…Functional imaging studies have shown activation of extrastriate cortical areas in early and, to a lesser extent, late blind subjects performing tactile tasks (Cohen et al, 1999;Sadato et al, 2002). According to several studies, primary visual cortex is activated only in early blind subjects (Sadato et al, 1996(Sadato et al, , 1998(Sadato et al, , 2002Cohen et al, 1999) (but see Büchel et al, 1998;Burton et al, 2002), yet tactile stimuli activated both striate and extrastriate cortex in sighted adults blindfolded for 5 d (PascualLeone and Hamilton, 2001). In several studies, the functional relevance of tactile occipital activation was confirmed through the use of disruptive transcranial magnetic stimulation (Cohen et al, 1997(Cohen et al, , 1999Pascual-Leone and Hamilton, 2001).…”
Section: Evidence That Loss Of Sight Itself Drives Tactile Acuity Enhmentioning
confidence: 99%
“…Plasticity has also been observed throughout the auditory pathway of both visually deprived animals [12,14,25,28] and early blind humans [6,17,26,36]. While these studies elucidate some heightened auditory skills in blind individuals (e.g., enhanced spatial localization), relatively few paradigms have examined auditory processing as compared to somatosensory or visual systems.…”
Section: Introductionmentioning
confidence: 99%