1986
DOI: 10.1093/ajcp/85.1.32
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Abstract: Vitamin B12 concentration was determined by radioassay in 179 healthy volunteers between the ages of 20 and 93 years in order to determine whether vitamin B12 levels decline with advancing age. The authors found no statistically significant decline in vitamin B12 levels in older individuals, nor a difference between males and females. A review of previous reports identifies potential reasons for controversy regarding the normal concentration of vitamin B12 in the elderly.

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Cited by 33 publications
(15 citation statements)
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“…Considering life cycle, B12 levels differs thought this study, as age sorting to range of 60-70 years and above 70 years brought significant difference, which in agreement of the review conducted concerned about old adults and vitamin B12 concentrations, it revealed the difference of levels among difference life cycle 27. Age and B12 levels were reversely correlated in this study, which in agreement of study conducted though subjects ranged between 22 and 93 years, the lowest levels of vitamin B12 found the elder contributors of the study 28 . Hemoglobin level positively correlated vitamin B12 levels, this similar of findings of many studies as well [29][30] .…”
Section: IIIsupporting
confidence: 89%
“…Considering life cycle, B12 levels differs thought this study, as age sorting to range of 60-70 years and above 70 years brought significant difference, which in agreement of the review conducted concerned about old adults and vitamin B12 concentrations, it revealed the difference of levels among difference life cycle 27. Age and B12 levels were reversely correlated in this study, which in agreement of study conducted though subjects ranged between 22 and 93 years, the lowest levels of vitamin B12 found the elder contributors of the study 28 . Hemoglobin level positively correlated vitamin B12 levels, this similar of findings of many studies as well [29][30] .…”
Section: IIIsupporting
confidence: 89%
“…An age‐related effect has been suggested in representative samples of elderly subjects 3–5 . Other workers have not found any relation between cobalamin concentrations and age in non‐selected populations 6–9 . In a review regarding this topic, Hitzhusen et al suggested bias in sample selection and differences in assay techniques as the reasons for the discordant results 6 …”
mentioning
confidence: 99%
“…This finding cannot be explained solely by the aging process, since vitamin B12 was only slightly related to age and also other reports have failed to show any age-dependent decline of serum vitamin B12 levels (Hitzhusen et al, 1986;McEvoy et al, 1982).…”
Section: Discussionmentioning
confidence: 61%