2000
DOI: 10.1089/jop.2000.16.261
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: A cationic biopolymer, chitosan, is proposed for use in artificial tear formulations. It is endowed with good wetting properties as well as an antibacterial effect that are desirable in cases of dry eye, which is often complicated by secondary infections. Solutions containing 0.5% w/v of a low molecular weight (M(w)) chitosan (160 kDa) were assessed for antibacterial efficacy against E. coli and S. aureus by using the usual broth-dilution technique. The in vitro evaluation showed that concentrations of chitosa… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
52
0

Year Published

2003
2003
2019
2019

Publication Types

Select...
7
3

Relationship

0
10

Authors

Journals

citations
Cited by 102 publications
(53 citation statements)
references
References 11 publications
1
52
0
Order By: Relevance
“…Chitosan's antibacterial activity was already observed at low concentrations against a variety of pathogens such as E. coli or S. aureus (Felt et al, 2000) and may be used in various formulation types such as gels (Yan et al, 2010), films (Mizuno et al, 2003) or nanoparticles (Hansson et al, 2012a). As a consequence, it is widely used in medical and veterinary areas as a wound healing promoter (Ishihara et al, 2001).…”
Section: Chitosan Formulationsmentioning
confidence: 99%
“…Chitosan's antibacterial activity was already observed at low concentrations against a variety of pathogens such as E. coli or S. aureus (Felt et al, 2000) and may be used in various formulation types such as gels (Yan et al, 2010), films (Mizuno et al, 2003) or nanoparticles (Hansson et al, 2012a). As a consequence, it is widely used in medical and veterinary areas as a wound healing promoter (Ishihara et al, 2001).…”
Section: Chitosan Formulationsmentioning
confidence: 99%
“…14,30 In addition, other useful properties of chitosan in solution such as its ability to change into a hydrogel at ocular pH (pH 7.4), its viscous nature and its bioadhesiveness make it a promising candidate for ocular drug delivery. 15,[30][31][32][33] These three properties are now discussed in more detail within the context of the results obtained in this study.…”
Section: Mechanism Of Controlled Releasementioning
confidence: 81%
“…Chitosan is reported to act as penetration enhancers that increase transcorneal permeation of the drug. Besides this, other properties of chitosan such as bioadhesiveness, viscous nature, and ability to convert into hydrogel at ocular pH (pH 7.4) make it the best suitable candidate for the development of this type of delivery systems (Lehr et al 1992;Felt et al 1998Felt et al , 2000. Poloxamers, commercially available as pluronics (Desai and Blanchard 1998), also possess all the necessary characteristics such as good thermal gelling, nonirritation to eye, and tolerance that make them suitable for ocular administration.…”
Section: Formulation and In Vitro Characterizationmentioning
confidence: 99%