<i>In vitro</i> Potential Effect of Morin in the Combination with β-Lactam Antibiotics Against Methicillin-Resistant <i>Staphylococcus aureus</i>

Mun, Su‐Hyun; Lee, Young‐Seob; Han, Sung-Hyun; Lee, Sang‐Won; Cha, Seon‐Woo; Kim, Sung‑Bae; Seo, Yun‐Soo; Kong, Ryong; Kang, Dahye; Shin, Dong‐Won; Kang, Ok‐Hwa; Kwon, Dong‐Yeul

doi:10.1089/fpd.2014.1923

Cited by 23 publications

(10 citation statements)

References 12 publications

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“…Previous reports have suggested a number of flavonoids as possible modifiers of MRSA cell wall and cell membrane [ 18 , 19 , 20 ]. Moreover, several polyhydroxylated flavonoids have demonstrated considerable synergistic effect with β-lactams antibiotics [ 16 , 21 ], and PBP2a has been suggested as the possible target [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Flavonoids as Potential anti-MRSA Agents through Modulation of PBP2a: A Computational and Experimental Study

et al. 2020

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Recently, the interest in plant-derived antimicrobial agents has increased. However, there are no sufficient studies dealing with their modes of action. Herein, we investigate an in-house library of common plant-based phenolic compounds for their potential antibacterial effects against the methicillin-resistant Staphylococcus aureus (MRSA), a widespread life-threatening superbug. Flavonoids, which are considered major constituents in the plant kingdom, were found to be a promising class of compounds against MRSA, particularly the non-glycosylated ones. On the other hand, the glycosylated derivatives, along with the flavonolignan silibinin A, were able to restore the inhibitory activity of ampicillin against MRSA. To explore the mode of action of this class, they were subjected to an extensive inverse virtual screening (IVS), which suggested penicillin-binding protein 2a (PBP2a) as a possible target that mediates both the antibacterial and the antibiotic-synergistic effects of this class of compounds. Further molecular docking and molecular dynamic simulation experiments were conducted to support the primary IVS and the in vitro results and to study their binding modes with PBP2a. Our findings shed a light on plant-derived natural products, notably flavonoids, as a promising and readily available source for future adjuvant antimicrobial therapy against resistant strains.

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Section: Discussionmentioning

confidence: 99%

Flavonoids as Potential anti-MRSA Agents through Modulation of PBP2a: A Computational and Experimental Study

et al. 2020

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“…Morin ( 45 ) is well‐known to be effective against Gram‐positive bacteria. Combination of this plant‐derived flavonol with conventional β‐lactam antibiotics against MRSA showed that the susceptibility of MRSA toward oxacillin was enhanced significantly (Mun et al, ). Bioactive constituents from Croton menyharthii evaluated for their inhibitory effects on selected bacteria.…”

Section: Antibacterial Activity Of Flavonoidsmentioning

confidence: 99%

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Farhadi

Khameneh

Iranshahi

et al. 2018

Phytotherapy Research

390

251

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Based on World Health Organization reports, resistance of bacteria to well-known antibiotics is a major global health challenge now and in the future. Different strategies have been proposed to tackle this problem including inhibition of multidrug resistance pumps and biofilm formation in bacteria and development of new antibiotics with novel mechanism of action. Flavonoids are a large class of natural compounds, have been extensively studied for their antibacterial activity, and more than 150 articles have been published on this topic since 2005. Over the past decade, some promising results were obtained with the antibacterial activity of flavonoids. In some cases, flavonoids (especially chalcones) showed up to sixfold stronger antibacterial activities than standard drugs in the market. Some synthetic derivatives of flavonoids also exhibited remarkable antibacterial activities with 20-to 80-fold more potent activity than the standard drug against multidrug-resistant Gram-negative and Gram-positive bacteria (including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus). This review summarizes the ever changing information on antibacterial activity of flavonoids since 2005, with a special focus on the structure-activity relationship and mechanisms of actions of this broad class of natural compounds.

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“…The resulting MIC for ampicillin was shifted from 800 to 107 μg/mL, and the MIC for ceftriaxone was shifted from 58 to 2.6 μg/mL. Similarly, Mun and colleagues also showed that a plant-derived flavonol, morin reversed the oxacillin-and ampicillin-treated MRSA [124]. Essential oils derived from Pituranthos chloranthus, Teucrium ramosissimum and Pistacia lentiscus also reduced the resistance of MRSA to various antibiotics in Penicillins' group such as amoxicillin, piperacillin, and oxacillin [125].…”

Section: Synergism Of Natural Products and Antibioticsmentioning

confidence: 87%

“…Mun and colleagues showed that the combination of morin and oxacillin synergistically killed the MRSA depending on the PBP2a-mediated resistance mechanism [124]. Another study demonstrated that the combination of ampicillin and Duabanga grandiflora extract inhibited the PBP2a protein [132].…”

Section: Penicillin-binding Protein 2a (Pbp2a)mentioning

confidence: 99%

Non-microbial Natural Products That Inhibit Drug-Resistant Staphylococcus aureus

Chew¹,

Peh²,

Yeang³

2019

Staphylococcus Aureus

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Drug resistance developed in human pathogenic bacteria is emerging and has become a global problem. Methicillin-resistant Staphylococcus aureus (MRSA) spreading in both hospital and community areas has posed a great impact to global public health. Current antibiotics used against these resistant strains are no longer efficacious and the search for new alternative is in urgent need. In the past decades, natural products have demonstrated multiple biological activities in biomedical areas including their antibacterial actions against various drug-resistant bacteria. More promisingly, some natural products could reverse the resistance of bacteria to the antibiotics, making the target bacteria susceptible to these drugs again. Numerous natural products have also exhibited potent synergism against the drug-resistant bacteria when used in combination with various types of antibiotics. Recently, several antibacterials derived from microbes have been developed and approved by Food and Drug Administration (FDA) for clinical use. In this chapter, we discuss the potential use of non-microbial natural products in controlling Staphylococcus aureus (S. aureus)'s growth, and the underlying challenges in developing the natural products into clinical applications.

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In vitro Potential Effect of Morin in the Combination with β-Lactam Antibiotics Against Methicillin-Resistant Staphylococcus aureus

Cited by 23 publications

References 12 publications

Flavonoids as Potential anti-MRSA Agents through Modulation of PBP2a: A Computational and Experimental Study

Flavonoids as Potential anti-MRSA Agents through Modulation of PBP2a: A Computational and Experimental Study

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Non-microbial Natural Products That Inhibit Drug-Resistant Staphylococcus aureus

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