2018
DOI: 10.1089/ars.2017.7214
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Abstract: We provide a rationale, based on modeling and experimental studies, for why Prx hyperoxidation should be considered a suitable, early biomarker for damaging levels of ROS. We discuss the implications that this has for the role of Prx in aging and the detection of hyperoxidized Prx as a conserved feature of circadian rhythms. Antioxid. Redox Signal. 28, 574-590.

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Cited by 58 publications
(41 citation statements)
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“…Indeed, many bacterial typical 2‐Cys peroxiredoxins are robust against hyperoxidation, without any apparent detrimental impact upon catalytic efficiency (Ferrer‐Sueta et al , ; Perkins et al , ). One possible reason for maintaining hyperoxidation sensitivity is that hyperoxidized peroxiredoxins serve specific functions within the cell, for example, recruitment of chaperones to protein aggregates (Hanzen et al , ) or prevention of excessive oxidation of important cellular redox couples and therefore maintenance of cell viability, as shown in this study and in others (Day et al , ; Veal et al , ). Other conserved motifs were recently shown to further fine‐tune peroxiredoxin hyperoxidation sensitivity (Bolduc et al , ), likely serving to tailor each peroxiredoxin to its specific function(s), localization, and the typical H 2 O 2 concentrations that it will encounter.…”
Section: Discussionsupporting
confidence: 63%
“…Indeed, many bacterial typical 2‐Cys peroxiredoxins are robust against hyperoxidation, without any apparent detrimental impact upon catalytic efficiency (Ferrer‐Sueta et al , ; Perkins et al , ). One possible reason for maintaining hyperoxidation sensitivity is that hyperoxidized peroxiredoxins serve specific functions within the cell, for example, recruitment of chaperones to protein aggregates (Hanzen et al , ) or prevention of excessive oxidation of important cellular redox couples and therefore maintenance of cell viability, as shown in this study and in others (Day et al , ; Veal et al , ). Other conserved motifs were recently shown to further fine‐tune peroxiredoxin hyperoxidation sensitivity (Bolduc et al , ), likely serving to tailor each peroxiredoxin to its specific function(s), localization, and the typical H 2 O 2 concentrations that it will encounter.…”
Section: Discussionsupporting
confidence: 63%
“…In gastric cancer, overexpression of PRDX5 alters the epithelial to mesenchymal transition (EMT) mechanism, with a poor prognosis for patients [ 77 ] being correlated. TXN recycles oxidized PRDXs, and this function is essential to balance intracellular oxidative stress [ 78 , 79 ]. The increased expression of TXN in prostate tissue has been positively correlated with the progression of Gleason score in patients with PCa [ 80 ], indicating that transformed cells express higher levels of Trx 1 compared with normal cells.…”
Section: Discussionmentioning
confidence: 99%
“…As mentioned in the introduction, the central redox machine has pleiotropic functions. In addition to detoxification of harmful amounts of ROS, they also act as sensors of oxidant concentrations and can even acquire new functions, such as chaperones activity for some Prxs [ 46 ] for a review. This sensor and/or transducer functions are very important given that the vast majority of redox-sensitive proteins are poorly sensitive to direct oxidation by H 2 O 2 (a possible exception, PTP1B, is discussed in [ 39 ]).…”
Section: The Redox Machinementioning
confidence: 99%