2003
DOI: 10.1088/0957-4484/14/12/001
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Abstract: We report the detection of DNA PCR amplicons using an ultrasensitive label-free electronic technique based on multiwalled carbon nanotube (MWNT) nanoelectrode arrays embedded in an SiO(2) matrix. Specific PCR amplicons are reliably detected using electrochemical (EC) methods through allele-specific oligonucleotide hybridization. The inherent guanine bases in the DNA amplicon target of [Formula: see text] bases serve as signal moieties with the aid of Ru(bpy)(3)(2+) mediators, providing an amplified anodic curr… Show more

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Cited by 180 publications
(103 citation statements)
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“…If the normalized differential curves of the first and second scans have a positive peak above the top dashed line, a positive conclusion can be drawn. These results obtained with ethylene glycol-passivated MWNT NEAs are consistent with previous data obtained with nonpassivated electrodes (15 ).…”
Section: Electrochemical Detection Algorithm Ac Voltammetry (Acv)supporting
confidence: 92%
“…If the normalized differential curves of the first and second scans have a positive peak above the top dashed line, a positive conclusion can be drawn. These results obtained with ethylene glycol-passivated MWNT NEAs are consistent with previous data obtained with nonpassivated electrodes (15 ).…”
Section: Electrochemical Detection Algorithm Ac Voltammetry (Acv)supporting
confidence: 92%
“…Therefore, it is concluded from Figure 3(c) that the conductivity decreases with increasing irradiation doses. The reduction of conductivity of SWCNTs thin film at room temperature with Ar and nitrogen (N) ion beam irradiation has been reported [15,24]. After annealing, the conductivity of the buckypaper was improved.…”
Section: Resultsmentioning
confidence: 98%
“…After annealing, the conductivity of the buckypaper was improved. Conductivity improvement after annealing ascribes that heating can give rise to a substantial drop in the defect number due to the migration of carbon atoms [13,15].…”
Section: Resultsmentioning
confidence: 99%
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“…Average CNT height and diameter were determined using scanning electron microscopy (SEM) to be approximately 5-8 µm and 100 nm, respectfully. A complete characterization of the growth process has been previously reported [4][5][6][7][8]. shows a cross-section of the CNT array after completion of the fabrication process.…”
Section: Cnt Nanoarray Electrodesmentioning
confidence: 99%