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Cited by 42 publications
(19 citation statements)
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“…Further studies in mice corroborated these data [14,15], while studies in human demonstrated associations between TLR4 mutations and LPS hyporesponsiveness[16]. We did not observe an association between the TLR4 Asp299Gly polymorphism in patients with tubal pathology although the study population was relatively small[17]. The lack of association can be explained by recent publications showing that heterozygous carriage of the TLR4 Asp299Gly mutation does not affect LPS responsiveness and that only the rare homozygous carriers are less responsive to LPS[18].…”
Section: Introductionsupporting
confidence: 60%
“…Further studies in mice corroborated these data [14,15], while studies in human demonstrated associations between TLR4 mutations and LPS hyporesponsiveness[16]. We did not observe an association between the TLR4 Asp299Gly polymorphism in patients with tubal pathology although the study population was relatively small[17]. The lack of association can be explained by recent publications showing that heterozygous carriage of the TLR4 Asp299Gly mutation does not affect LPS responsiveness and that only the rare homozygous carriers are less responsive to LPS[18].…”
Section: Introductionsupporting
confidence: 60%
“…These data argue against a direct role for cHSP60-induced TLR4-mediated tissue damage in genital tract infection but does not rule out a role for HSP60 in the pathological process. Interestingly, a recent report by Morre et al (77) found no association of the functional polymorphism in the gene encoding TLR4 function (Asp 299 Gly) with tubal infertility in C. trachomatis IgG-positive Dutch women.…”
Section: Discussionmentioning
confidence: 95%
“…Whereas some studies have suggested an increased susceptibility to Gram-negative infections or Gram-negative septic shock [72,73], others have been unable to find a role of this polymorphism in meningococcal disease [74], polymicrobial sepsis [75], and urogenital tract Candida and Chlamydia infection [76,77]. Controversy also surrounds the functional consequences of this mutation: Whereas initial studies suggested hyporesponsiveness to LPS in individuals bearing this mutation [78], recent studies have failed to confirm this [79,80].…”
Section: Tlrs In Human Infectious Diseasesmentioning
confidence: 99%