2001
DOI: 10.1083/jcb.200104025
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Development of oligodendrocytes and the generation of myelin internodes within the spinal cord depends on regional signals derived from the notochord and axonally derived signals. Neuregulin 1 (NRG)-1, localized in the floor plate as well as in motor and sensory neurons, is necessary for normal oligodendrocyte development. Oligodendrocytes respond to NRGs by activating members of the erbB receptor tyrosine kinase family. Here, we show that erbB2 is not necessary for the early stages of oligodendrocyte precurso… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
68
0
1

Year Published

2003
2003
2012
2012

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 98 publications
(70 citation statements)
references
References 101 publications
1
68
0
1
Order By: Relevance
“…2). All EGFR family members were present during oligodendrocyte progenitor appearance The normal development of oligodendrocytes in the absence of ErbB4 signaling was surprising because neuregulin-1 is required for oligodendrocyte development (Vartanian et al, 1999), and this effect is independent of ErbB2 and ErbB3 (Park et al, 2001;Stolt et al, 2002;Schmucker et al, 2003). Together, these results suggest that there is functional redundancy among neuregulin receptors during early oligodendrocyte development.…”
Section: Absence Of Erbb4 Did Not Affect the Development Of Mab O4mentioning
confidence: 99%
See 1 more Smart Citation
“…2). All EGFR family members were present during oligodendrocyte progenitor appearance The normal development of oligodendrocytes in the absence of ErbB4 signaling was surprising because neuregulin-1 is required for oligodendrocyte development (Vartanian et al, 1999), and this effect is independent of ErbB2 and ErbB3 (Park et al, 2001;Stolt et al, 2002;Schmucker et al, 2003). Together, these results suggest that there is functional redundancy among neuregulin receptors during early oligodendrocyte development.…”
Section: Absence Of Erbb4 Did Not Affect the Development Of Mab O4mentioning
confidence: 99%
“…Neuregulins signal through homodimerized or heterodimerized receptors of the epidermal growth factor receptor (EGFR) family, EGFR, ErbB2, ErbB3, and ErbB4 (Yarden and Sliwkowski, 2001;Murphy et al, 2002;Carpenter, 2003;Citri et al, 2003). Studies investigating ErbB2 and ErbB3 demonstrate that neither is required for oligodendrocyte progenitor development (Park et al, 2001;Stolt et al, 2002;Kim et al, 2003;Schmucker et al, 2003). Although ErbB2 appears important in the transition from progenitor to differentiated oligodendrocyte, ErbB3 is dispensable for oligodendrocyte maturation.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, mice deficient in ErbB2 show defects in cranial sensory ganglia likely due to defects in cranial neural crest [119,123]. ErbB2 plays a role in the terminal differentiation of oligodendrocyte precursors to mature oligodendrocytes in the spinal cord [124] as well as in the myelination of peripheral nerves by Schwann cells [125][126][127]. Rescue of the embryonic lethal cardiac defects of ErbB2-deficient mice by myocardium-restricted expression of wild-type ErbB2 results in mice with severe defects in Schwann cell migration in the peripheral nervous system with loss of sensory and motor neurons [125,126].…”
Section: Erbb Members In Mammalian Developmentmentioning
confidence: 99%
“…Another interesting finding is the detection of neuroglycan C gene expression, which has been recently characterized as a novel ErbB3/ErbB2 ligand (Kinugasa et al, 2004). This is interesting, because ErbB2 activation enhances OL differentiation and survival (Fernandez et al, 2000;Park et al, 2001;Kim et al, 2003), suggesting the possibility that, in the early stages of OL differentiation, OPC-derived neuroglycan C could provide support for newly forming OLs until they tightly wrap axons, whereupon the axonally expressed ErbB2 ligand neuregulin could then support myelinating OLs (Barres and Raff, 1999).…”
Section: Analysis Of the Genes Most Highly Expressed By Opcsmentioning
confidence: 99%