2011
DOI: 10.1080/10937404.2011.556045
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Abstract: Although asbestos research has been ongoing for decades, this increased knowledge has not led to consensus in many areas of the field. Two such areas of controversy include the specific definitions of asbestos, and limitations in understanding exposure-response relationships for various asbestos types and exposure levels and disease. This document reviews the current regulatory and mineralogical definitions and how variability in these definitions has led to difficulties in the discussion and comparison of bot… Show more

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Cited by 100 publications
(94 citation statements)
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“…Sixty-nine percent of the amphibole particles measured and 97% of amphibole fibers were <3 mm in diameter and are thus considered respirable (National Research Council, 1984, p. 25-47). Fibers with aspect ratios >3:1 and those that are longer than 5 mm are more toxic (Aust et al, 2011;Case et al, 2011). In this study, we found that 100% of all amphibole fibers and 97% of all amphibole particles had aspect ratios >3:1 (Fig.…”
Section: Morphologymentioning
confidence: 51%
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“…Sixty-nine percent of the amphibole particles measured and 97% of amphibole fibers were <3 mm in diameter and are thus considered respirable (National Research Council, 1984, p. 25-47). Fibers with aspect ratios >3:1 and those that are longer than 5 mm are more toxic (Aust et al, 2011;Case et al, 2011). In this study, we found that 100% of all amphibole fibers and 97% of all amphibole particles had aspect ratios >3:1 (Fig.…”
Section: Morphologymentioning
confidence: 51%
“…Toxicity is related to the width, length, aspect ratio, surface area, and surface chemical composition of the mineral fiber (Aust et al, 2011). Separable fibers longer than 5 mm with aspect ratios ³3:1 and those that contain Fe are considered to be more toxic (Aust et al, 2011;Case et al, 2011). Morphology, along with amphibole classification, is at the heart of controversies over the potential public health risks and the necessity for remediation represented by naturally occurring asbestos.…”
mentioning
confidence: 99%
“…The early pioneering intracavitary instillation and implantation studies of Freidrich Pott and coworkers (Pott, 1980;Pott et al, 1974) and Merle Stanton and colleagues (Stanton et al, 1969(Stanton et al, , 1977(Stanton et al, , 1981 revealed that the physical properties of fibers such as dimension are important in the pathogenesis of asbestosassociated disease of the serosal tissues (Case et al, 2011;Aust et al, 2011).…”
Section: Biological Mechanisms Responsible For Non-neoplastic Pleuralmentioning
confidence: 99%
“…These tissue samples were obtained from cases throughout the United States that were sent to Dr. Suzuki for pathological review and were systematically analyzed using histology, immunohistochemistry, and electron microscopy, in some cases, over a 15-yr period. As summarized succinctly by Dumortier et al (1998) in a letter to the editor in 1998, the size and type of asbestos fibers associated with development of diffuse malignant pleural mesothelioma remain controversial (Mossman et al, 2011;Case et al, 2011;Aust et al, 2011).…”
Section: Pleural Fiber Dosimetry In Humansmentioning
confidence: 99%
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