Enhancement of curcumin antitumor efficacy and further photothermal ablation of tumor growth by single-walled carbon nanotubes delivery system <i>in vivo</i>

Li, Haixia; Zhang, Nan; Hao, Yongwei; Wang, Yali; Jia, Shasha; Zhang, Hongling

doi:10.1080/10717544.2019.1672829

Cited by 31 publications

(8 citation statements)

References 34 publications

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“…It is worth mentioning that both DOX and curcumin suffer from poor bioavailability. In light of this, a wide variety of nanoplatforms have been developed for codelivery of curcumin and DOX [ 179 , 180 , 181 ]. In addition to promoting cellular internalization of DOX, nanocarriers can prevent development of chemoresistance, since a low amount of DOX is loaded on/in the encapsulants.…”

Section: Codelivery Via Biological Nanovehiclesmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

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Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin, paclitaxel, docetaxel, etoposide and oxaliplatin, cancer cells are able to obtain chemoresistance that limits DOX efficacy. In respect to dose-dependent side effect of DOX, enhancing its dosage is not recommended for effective cancer chemotherapy. Therefore, different strategies have been considered for reversing DOX resistance and diminishing its side effects. Phytochemical are potential candidates in this case due to their great pharmacological activities. Curcumin is a potential antitumor phytochemical isolated from Curcuma longa with capacity of suppressing cancer metastasis and proliferation and affecting molecular pathways. Experiments have demonstrated the potential of curcumin for inhibiting chemoresistance by downregulating oncogene pathways such as MMP-2, TGF-β, EMT, PI3K/Akt, NF-κB and AP-1. Furthermore, coadministration of curcumin and DOX potentiates apoptosis induction in cancer cells. In light of this, nanoplatforms have been employed for codelivery of curcumin and DOX. This results in promoting the bioavailability and internalization of the aforementioned active compounds in cancer cells and, consequently, enhancing their antitumor activity. Noteworthy, curcumin has been applied for reducing adverse effects of DOX on normal cells and tissues via reducing inflammation, oxidative stress and apoptosis. The current review highlights the anticancer mechanism, side effects and codelivery of curcumin and DOX via nanovehicles.

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Section: Codelivery Via Biological Nanovehiclesmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

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“…Curcumin administration to male Kumming mice, subcutaneously injected with S180 cells, resulted in improved survival and reduced tumor volume and weight [115]. Additionally, curcumin administration increased cell necrosis, lysis, and fragmentation [115].…”

Section: Effects Of Curcumin On Prostate Cancer In Vivomentioning

confidence: 99%

“…Many studies have examined the effects of curcumin treatment on animals (mice) xenografted with different human prostate cancer cells and is presented in Table 6 and Figure 4. [85,86,88,[103][104][105][106][107][108][109][110][111][112][113][114][115][116][117] and created using BioRender.com. [85,86,88,[103][104][105][106][107][108][109][110][111][112][113][114][115][116][117] and created using BioRender.com.…”

Section: Effects Of Curcumin On Prostate Cancer In Vivomentioning

confidence: 99%

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Curcumin against Prostate Cancer: Current Evidence

et al. 2020

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Cancer is a condition characterized by remarkably enhanced rates of cell proliferation paired with evasion of cell death. These deregulated cellular processes take place following genetic mutations leading to the activation of oncogenes, the loss of tumor suppressor genes, and the disruption of key signaling pathways that control and promote homeostasis. Plant extracts and plant-derived compounds have historically been utilized as medicinal remedies in different cultures due to their anti-inflammatory, antioxidant, and antimicrobial properties. Many chemotherapeutic agents used in the treatment of cancer are derived from plants, and the scientific interest in discovering plant-derived chemicals with anticancer potential continues today. Curcumin, a turmeric-derived polyphenol, has been reported to possess antiproliferative and proapoptotic properties. In the present review, we summarize all the in vitro and in vivo studies examining the effects of curcumin in prostate cancer.

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“…Morais et al [91] demonstrated that the naringenin-functionalized CNTs showed lower cytotoxicity on non-malignant cells (hFB) than free naringenin, with an improved anti-cancer effect on malignant lung cells (A549) as an in vitro model of lung cancer. Li et al [92] reported that a novel delivery system for curcumin using functionalized single-walled carbon nanotubes by phosphatidylcholine and polyvinylpyrrolidone (SWCNT-Cur) exhibited significantly higher inhibition efficacy on tumor growth and no obvious toxicity in the main organs in a murine S180 tumor model. Moreover, photothermal therapy induced by SWCNTs under near-infrared radiation further facilitated SWCNT-Cur to inhibit the tumor growth in vivo.…”

Section: (B) Carbon-based Nanoparticlesmentioning

confidence: 99%

Nanomaterials as Promising Theranostic Tools in Nanomedicine and Their Applications in Clinical Disease Diagnosis and Treatment

et al. 2021

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In recent decades, with the rapid development of nanotechnology, nanomaterials have been widely used in the medical field, showing great potential due to their unique physical and chemical properties including minimal size and functionalized surface characteristics. Nanomaterials such as metal nanoparticles and polymeric nanoparticles have been extensively studied in the diagnosis and treatment of diseases that seriously threaten human life and health, and are regarded to significantly improve the disadvantages of traditional diagnosis and treatment platforms, such as poor effectiveness, low sensitivity, weak security and low economy. In this review, we report and discuss the development and application of nanomaterials in the diagnosis and treatment of diseases based mainly on published research in the last five years. We first briefly introduce the improvement of several nanomaterials in imaging diagnosis and genomic sequencing. We then focus on the application of nanomaterials in the treatment of diseases, and select three diseases that people are most concerned about and that do the most harm: tumor, COVID-19 and cardiovascular diseases. First, we introduce the characteristics of nanoparticles according to the excellent effect of nanoparticles as delivery carriers of anti-tumor drugs. We then review the application of various nanoparticles in tumor therapy according to the classification of nanoparticles, and emphasize the importance of functionalization of nanomaterials. Second, COVID-19 has been the hottest issue in the health field in the past two years, and nanomaterials have also appeared in the relevant treatment. We enumerate the application of nanomaterials in various stages of viral pathogenesis according to the molecular mechanism of the complete pathway of viral infection, pathogenesis and transmission, and predict the application prospect of nanomaterials in the treatment of COVID-19. Third, aiming at the most important causes of human death, we focus on atherosclerosis, aneurysms and myocardial infarction, three of the most common and most harmful cardiovascular diseases, and prove that nanomaterials could be involved in a variety of therapeutic approaches and significantly improve the therapeutic effect in cardiovascular diseases. Therefore, we believe nanotechnology will become more widely involved in the diagnosis and treatment of diseases in the future, potentially helping to overcome bottlenecks under existing medical methods.

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Enhancement of curcumin antitumor efficacy and further photothermal ablation of tumor growth by single-walled carbon nanotubes delivery system in vivo

Abstract: (2019) Enhancement of curcumin antitumor efficacy and further photothermal ablation of tumor growth by single-walled carbon nanotubes delivery system invivo,

Cited by 31 publications

References 34 publications

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Curcumin against Prostate Cancer: Current Evidence

Nanomaterials as Promising Theranostic Tools in Nanomedicine and Their Applications in Clinical Disease Diagnosis and Treatment

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