Carbon-based nanomaterials for targeted cancer nanotherapy: recent trends and future prospects

Nanotechnology has opened up a world of possibilities for the treatment of brain disorders. Nanosystems can be designed to encapsulate, carry, and deliver a variety of therapeutic agents, including drugs and nucleic acids. Nanoparticles may also be formulated to contain photosensitizers or, on their own, serve as photothermal conversion agents for phototherapy. Furthermore, nano-delivery agents can enhance the efficacy of contrast agents for improved brain imaging and diagnostics. However, effective nano-delivery to the brain is seriously hampered by the formidable blood–brain barrier (BBB). Advances in understanding natural transport routes across the BBB have led to receptor-mediated transcytosis being exploited as a possible means of nanoparticle uptake. In this regard, the oligopeptide Angiopep-2, which has high BBB transcytosis capacity, has been utilized as a targeting ligand. Various organic and inorganic nanostructures have been functionalized with Angiopep-2 to direct therapeutic and diagnostic agents to the brain. Not only have these shown great promise in the treatment and diagnosis of brain cancer but they have also been investigated for the treatment of brain injury, stroke, epilepsy, Parkinson’s disease, and Alzheimer’s disease. This review focuses on studies conducted from 2010 to 2021 with Angiopep-2-modified nanoparticles aimed at the treatment and diagnosis of brain disorders.

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“…Toxic if not functionalized. [82][83][84][85] Magnetic Nanoparticles Biocompatible and easy to synthesize.…”

Section: Carbon-based Nanoparticlesmentioning

confidence: 99%

Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review

Habib

Singh

2022

Polymers

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“…Thus, cancer investigation pursues treatments to minimize these undesirable side effects, touching to the excellent capable, innovative therapies, for example, nanomedicine and drug delivery [14].…”

Section: Abstract a R T I C L E I N F O R M A T I O Nmentioning

confidence: 99%

Application of carbon allotropes composites for targeted cancer therapy drugs: A review

Niazvand¹,

Wagh

Khazraei

et al. 2021

jcc

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In recent years, various drug carrier nanomaterials have been investigated to improve drug delivery systems in cancer treatment. However, an ongoing requirement exists for more beneficial therapeutic materials, yielding rapid clearance, high capacity for reducing systemic toxicity via specific-tumor targeting, and superior drug solubility. Given that, carbon allotropes, including Active Carbon (AC), carbon nanotubes (CNTs), graphene and graphene oxides (GOs), nanodiamonds (NDs), fullerenes, carbon nanohorns, soporous carbons, and carbon dots, have been studied owing to their high thermal conductivity, rigid structure, flexibility for modification and functionalization, adequate surface-to-volume ratio, and high biocompatibility. This review aims to overview recent advances in applying different carbon allotrope composites in drug delivery-based cancer therapy systems.

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“…Among the various nanomaterials, carbon-based nanomaterials, such as graphene, carbon nanotubes, fullerene, and nanodiamonds, are ideal precursors for use in various elds, particularly in the fabrication of biomaterials, drug delivery systems (DDSs), and cancer diagnostic and therapeutic applications. 39,40 Owing to the intrinsic hydrophobic nature of carbon-based nanomaterials, it seems that their combination with hydrophilic polymers such as HPG will have benets. In this review, we focus on modifying carbon-based nanomaterials, including graphene, carbon nanotubes, fullerene, nanodiamonds, carbon dots, and carbon bers by HPG, as well as their various applications in recent studies.…”

Section: Introductionmentioning

confidence: 99%

Modification of carbon-based nanomaterials by polyglycerol: recent advances and applications

Rafiee

Omidi

2022

RSC Adv.

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Carbon-based nanomaterials for targeted cancer nanotherapy: recent trends and future prospects

Cited by 58 publications

References 210 publications

Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review

Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review

Application of carbon allotropes composites for targeted cancer therapy drugs: A review

Modification of carbon-based nanomaterials by polyglycerol: recent advances and applications

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