2002
DOI: 10.1080/02652040110081406
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Abstract: Poly(ethylcyanoacrylate) (PECA) nanospheres have been employed as biodegradable polymeric carriers for oral (po) delivery of insulin. The main goal of this investigation was to screen various absorption enhancers, which were used to protect insulin-loaded PECA, by following their in vivo performance after oral administrations to streptozotocin-induced diabetic rats. The nanospheres were prepared by polymerization in a continuous aqueous phase at pH 2.5 and in the presence of Pluronic 68 (0.5%). This polymeriza… Show more

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Cited by 74 publications
(28 citation statements)
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“…GA and its derivatives have been utilized in enhancing drug absorption (Tanaka et al, 1992;Imai et al, 1999;Radwan & Aboul-Enein, 2002;Cho et al, 2004;Anand et al, 2010). Significant enhanced rectal absorption of AMB suppositories in rabbits following GA addition in comparison to formulation containing no GA (Tanaka et al, 1992;Anand et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…GA and its derivatives have been utilized in enhancing drug absorption (Tanaka et al, 1992;Imai et al, 1999;Radwan & Aboul-Enein, 2002;Cho et al, 2004;Anand et al, 2010). Significant enhanced rectal absorption of AMB suppositories in rabbits following GA addition in comparison to formulation containing no GA (Tanaka et al, 1992;Anand et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…In order to circumvent the problems associated with parenteral administration of insulin, alternative strategies have been suggested in the literature including co-administration with absorption enhancers [6] or enzyme inhibitors, chemical modification [7], polymeric micro/ nano carriers [8], lipid-based carriers as liposomes [9], solid lipid nanoparticles (NPs) [10], etc. Hitherto, each of these developments met with a limited success and no commercially acceptable oral insulin product is available for human use.…”
Section: Introductionmentioning
confidence: 99%
“…Streptozotocin was freshly dissolved in 0.1 M citrate buffer (pH = 4.5) at the dose of 60 mg/kg ISRN Nanotechnology 3 body weight and injected intraperitoneally. Blood glucose level was estimated at 0 hr and repeated after a gap of 1 hr of experiment with the help of glucometer using glucose strip method and blood was taken from tail tip of the rat [12]. Rats having blood glucose level more than 250 mg/dL were separated and divided into six different groups comprising of 6 rats in each group for the antidiabetic study.…”
Section: In Vivo Pharmacological Studiesmentioning
confidence: 99%