“…These co-activators function either as adapters, serving in the assembly of transcription initiation complexes, or they are involved in diverse modifications of chromatin proteins, including the receptor itself, or in chromatin remodeling. Thus, histone acetyl transferases, such as SRC-1/p160 and p300/CBP, and methyl transferases, such as CARM-1, were identified as co-activators of nuclear receptors, whereas corepressors exhibit or recruit histone deacetylase activity (for reviews, see Rosenfeld and Glass, 2001;McKenna and O'malley, 2002;Lonard and O'Malley, 2006).…”