2001
DOI: 10.1074/jbc.r100041200
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Members of the nuclear receptor superfamily directly activate or repress target genes by binding to hormone response elements (HREs) 1 in promoter or enhancer regions, and by binding to other DNA sequence-specific activators and can inhibit the transcriptional activities of other classes of transcription factors by transrepression. Hormone response elements provide specificity to receptor homodimer heterodimer binding (reviewed in Ref.2). Nuclear receptor functions are directed by specific activation domains, … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

3
369
1
4

Year Published

2004
2004
2015
2015

Publication Types

Select...
5
5

Relationship

0
10

Authors

Journals

citations
Cited by 463 publications
(377 citation statements)
references
References 72 publications
3
369
1
4
Order By: Relevance
“…TPA might down-regulate PSA by inhibiting the PI3K/AKT signal pathway. The regulation of gene transcription by nuclear receptors requires the recruitment of a number of proteins characterized as coregulators, functioning either as co-activators or co-repressors (Glass and Rosenfeld, 2000;Rosenfeld and Glass, 2001). Further studies will explore if TPA could inhibit the recruitment of co-activators or promote the recruitment of co-repressors of AR.…”
Section: Discussionmentioning
confidence: 99%
“…TPA might down-regulate PSA by inhibiting the PI3K/AKT signal pathway. The regulation of gene transcription by nuclear receptors requires the recruitment of a number of proteins characterized as coregulators, functioning either as co-activators or co-repressors (Glass and Rosenfeld, 2000;Rosenfeld and Glass, 2001). Further studies will explore if TPA could inhibit the recruitment of co-activators or promote the recruitment of co-repressors of AR.…”
Section: Discussionmentioning
confidence: 99%
“…Gene expression during long-term synaptic plasticity requires the activation of transcription factors, as well as chromatin remodeling (Wolffe and Hayes, 1999;Rosenfeld and Glass, 2001). As a regulator of gene expression, PARP-1 seems to play a critical role in both these processes.…”
Section: Discussionmentioning
confidence: 99%
“…These co-activators function either as adapters, serving in the assembly of transcription initiation complexes, or they are involved in diverse modifications of chromatin proteins, including the receptor itself, or in chromatin remodeling. Thus, histone acetyl transferases, such as SRC-1/p160 and p300/CBP, and methyl transferases, such as CARM-1, were identified as co-activators of nuclear receptors, whereas corepressors exhibit or recruit histone deacetylase activity (for reviews, see Rosenfeld and Glass, 2001;McKenna and O'malley, 2002;Lonard and O'Malley, 2006).…”
Section: Introductionmentioning
confidence: 99%