2002
DOI: 10.1074/jbc.m203184200
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: As the expression of cyclin D1 is induced during liver regeneration and also in hepatic tumor cells, cyclin D1 is likely to play an important role in the proliferation and transformation of hepatocytes. However, the role of cyclin D1 in liver development remains unknown. Here we show that the expression of D-type cyclins including cyclin D1, D2, and D3 is down-regulated along with liver development. In addition, oncostatin M (OSM), an interleukin-6 family cytokine, down-regulated the expression of cyclin D1 an… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

6
41
0

Year Published

2004
2004
2009
2009

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 63 publications
(47 citation statements)
references
References 47 publications
6
41
0
Order By: Relevance
“…However, the presence of activated STAT3 does not necessarily result in increased expression of cyclin D1 in all cells. For example, in normal rat fetal liver cells, STAT3 activation by cytokines or introduction of STAT3-C led to a decrease in cyclin D1 mRNA levels (27). These data suggest that activated STAT3 can initiate cyclin D1 transcription in conjunction with other transcription factors, which may not be found in certain normal cells.…”
Section: Discussionmentioning
confidence: 77%
See 1 more Smart Citation
“…However, the presence of activated STAT3 does not necessarily result in increased expression of cyclin D1 in all cells. For example, in normal rat fetal liver cells, STAT3 activation by cytokines or introduction of STAT3-C led to a decrease in cyclin D1 mRNA levels (27). These data suggest that activated STAT3 can initiate cyclin D1 transcription in conjunction with other transcription factors, which may not be found in certain normal cells.…”
Section: Discussionmentioning
confidence: 77%
“…High levels of activated STAT3 correlate positively with elevated cyclin D1 mRNA and protein expression in both cell lines and tumors (20,(27)(28)(29)(30)(31)(32). We and others previously reported that by immunohistochemical analysis of tissue microarrays (TMA) of primary breast cancer specimens (36 tumors and 8 normal), 28% contain high levels (+++) of nuclear phospho-STAT3 (pYSTAT3), 33% contain moderate levels of pYstat3 (++), and 39% contain no to little pYSTAT3 (5,33).…”
Section: Resultsmentioning
confidence: 99%
“…In contrast, growth arrest through upregulation of the cell cycle inhibitors p21 waf1/cip1 , p27 kip1 and neuroendocrine differentiation are also induced by STAT3 signaling (Minami et al, 1996;Nakajima et al, 1996;Florenes et al, 1999;Kortylewski et al, 1999;Spiotto and Chung, 2000). For example, STAT3 is described to act as a negative regulator of cyclin D1 transcription during fetal liver development, whereas it positively regulates cyclin D1 expression in hepatoma cells and the initial phase of liver regeneration (Matsui et al, 2002). Therefore, it is very likely that the transforming potential of STAT3 is tightly dependent on oncogenic pathways already activated in a given cell type and its engagement with upstream signals that trigger its activation.…”
Section: Discussionmentioning
confidence: 99%
“…Because the JAK-STAT pathway is involved in tissue protection in various kinds of hepatic injuries, 28,29 up-regulation of the JAK-STAT signaling in KK-A y mice is considered as a stress-related protective response in the liver. Importantly, it has been reported that excess phosphorylation of STAT3 results in poor hepatic regeneration because of direct down-regulation of cyclin D1 expression 26,30,31 and that higher SOCS-3 expression in hepatocytes lacking gp130-dependent Ras correlates with delayed hepatocyte proliferation. 32 Collectively, these findings are consistent with the hypothesis that sustained activation of the JAK-STAT pathway leads to inhibition of cyclin D1, thereby causing regeneration failure in KK-A y mice.…”
Section: Discussionmentioning
confidence: 99%