1996
DOI: 10.1073/pnas.93.22.12406
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Abstract: A number of aberrant morphological phenotypes were noted during propagation of the Arabidopsis thaliana DNA hypomethylation mutant, ddm1, by repeated self-pollination. Onset of a spectrum of morphological abnormalities, including defects in leaf structure, flowering time, and flower structure, was strictly associated with the ddm1 mutations. The morphological phenotypes arose at a high frequency in selfed ddm1 mutant lines and some phenotypes became progressively more severe in advancing generations. The trans… Show more

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Cited by 355 publications
(287 citation statements)
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“…Because TEs are known to be able to modulate gene expression, and regulate host genes differentially during the embryonic development (Peaston et al, 2004), many changes in individual phenotypes are to be expected. This is consistent with the report that epigenetic processes, which involve chromatin remodeling proteins that control TE expression, may contribute to the loss of fitness due to inbreeding in Arabidopsis (Kakutani et al, 1996). There is also evidence that some imprinting genes are acquired from retrotransposons and that retrotransposon silencing by DNA methylation can drive genomic imprinting in mammals and in plants (see Gifford et al (2013) for a review).…”
supporting
confidence: 87%
“…Because TEs are known to be able to modulate gene expression, and regulate host genes differentially during the embryonic development (Peaston et al, 2004), many changes in individual phenotypes are to be expected. This is consistent with the report that epigenetic processes, which involve chromatin remodeling proteins that control TE expression, may contribute to the loss of fitness due to inbreeding in Arabidopsis (Kakutani et al, 1996). There is also evidence that some imprinting genes are acquired from retrotransposons and that retrotransposon silencing by DNA methylation can drive genomic imprinting in mammals and in plants (see Gifford et al (2013) for a review).…”
supporting
confidence: 87%
“…The DDM1 protein belongs to the SWI/SNF family of chromatin-remodeling factors, and loss of DDM1 is known to cause both a global genome hypomethylation and a redistribution of methylation profiles at some loci (Kakutani et al 1996;Jacobsen et al 2000). Like DDM1, the MORPHEUS MOLECULE (MOM) gene also encodes a SWI/SNF-like protein that, similar to DDM1, can also release transcriptional gene silencing.…”
Section: Phe1ϻgus Is Expressed In the Absence Of Fertilization In Fiementioning
confidence: 99%
“…normal development of animals 10,11 and plants [12][13][14] via effects on gene repression 15 , Xchromosome inactivation 16 , genomic imprinting 17 and replication timing 18 .…”
mentioning
confidence: 99%