2021
DOI: 10.1073/pnas.2024358118
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Abstract: Although most patients recover from acute COVID-19, some experience postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC). One subgroup of PASC is a syndrome called “long COVID-19,” reminiscent of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS is a debilitating condition, often triggered by viral and bacterial infections, leading to years-long debilitating symptoms including profound fatigue, postexertional malaise, unrefreshing sleep, cognitive deficits, a… Show more

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Cited by 146 publications
(125 citation statements)
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“…However, oxidative stress has more recently been defined as a disruption of redox signaling pathways [ 67 ]. Elevated oxidative stress is at the heart of several neurodegenerative diseases, as well as other conditions [ 68 , 69 ]. Decreased levels and/or dysregulated metabolism of the antioxidants such as ascorbate (vitamin C), glutathione (GSH) and cysteine, and coenzyme Q10 (CoQ10) have been observed in HD and contribute to disease pathology [ 70 , 71 , 72 ].…”
Section: Golgi Stress Response and Redox Imbalance In Neurodegeneration: Focus On Huntington’s Diseasementioning
confidence: 99%
“…However, oxidative stress has more recently been defined as a disruption of redox signaling pathways [ 67 ]. Elevated oxidative stress is at the heart of several neurodegenerative diseases, as well as other conditions [ 68 , 69 ]. Decreased levels and/or dysregulated metabolism of the antioxidants such as ascorbate (vitamin C), glutathione (GSH) and cysteine, and coenzyme Q10 (CoQ10) have been observed in HD and contribute to disease pathology [ 70 , 71 , 72 ].…”
Section: Golgi Stress Response and Redox Imbalance In Neurodegeneration: Focus On Huntington’s Diseasementioning
confidence: 99%
“…Inflammatory activity, via proinflammatory cytokines can cause mitochondrial fragmentation and dysfunction 308 , and there is now good evidence that inflammation is intimately linked to energy metabolism. 309 Also, cytokines like TNF alpha can derange mitochondrial energy production and induce mitochondria to produce ROS thereby amplifying the inflammatory process. So clearly, mitochondrial dysfunction may be both cause and effect of inflammatory processes: inflammation may impede mitochondrial function, but mitochondrial dysfunction may also promote inflammation.…”
Section: Mitochondrial Cellular and "Metabolic" Dysfunctionmentioning
confidence: 99%
“…The common theme of post-viral fatigue, regardless of the pathogen, is that it is more frequent, severe, and prolonged in women than in men [ 120 , 121 , 122 , 123 ]. For this reason, physicians [ 134 ] and scientists [ 135 ] are linking the pathogenesis and clinical signs and symptoms of PASC with a similar disabling condition known as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) [ 136 ]. ME/CFS also disproportionately affects women (especially White/Caucasian women) and was first described as “yuppy flu” in the 1980s due to its poorly understood psychological and physical (e.g., fatigue) manifestations [ 135 ].…”
Section: Women Pa and Post-acute Sequelae Of Sars-cov-2 Infection (Pasc)mentioning
confidence: 99%