2001
DOI: 10.1073/pnas.131128898
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: An emerging and important site of action for nitric oxide (NO) within cells is the mitochondrial inner membrane, where NO binds to and inhibits members of the electron transport chain, complex III and cytochrome c oxidase. Although it is known that inhibition of cytochrome c oxidase by NO is competitive with O 2, the mechanisms that underlie this phenomenon remain unclear, and the impact of both NO and O2 partitioning into biological membranes has not been considered. These properties are particularly interest… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

7
152
0
1

Year Published

2002
2002
2021
2021

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 202 publications
(160 citation statements)
references
References 39 publications
(47 reference statements)
7
152
0
1
Order By: Relevance
“…By injecting NO into the solution containing the aorta, we could simultaneously observe both the NO inhibition of aortic O 2 consumption and the effect of O 2 concentrations on aortic NO consumption. Our results show that NO can inhibit the aortic O 2 consumption, which is consistent with previous results from mitochondria (5,9,16,17), cells (1,4,10), and tissues (3,24). In the meantime, the rate of aortic NO consumption also depends on O 2 concentration.…”
Section: Discussionsupporting
confidence: 92%
See 3 more Smart Citations
“…By injecting NO into the solution containing the aorta, we could simultaneously observe both the NO inhibition of aortic O 2 consumption and the effect of O 2 concentrations on aortic NO consumption. Our results show that NO can inhibit the aortic O 2 consumption, which is consistent with previous results from mitochondria (5,9,16,17), cells (1,4,10), and tissues (3,24). In the meantime, the rate of aortic NO consumption also depends on O 2 concentration.…”
Section: Discussionsupporting
confidence: 92%
“…Removing endothelium from the aorta did not appreciably change the NO consumption rate (data not shown). This NO inhibition of aortic O 2 consumption and the effect of O 2 concentration on aortic NO consumption before O 2 concentration dropped to 0 are similar to the results observed from isolated mitochondria (9,17,18), implying that Fig. 1.…”
Section: Resultssupporting
confidence: 84%
See 2 more Smart Citations
“…Specifically, the Snitrosylated proteins closely colocalized with mitochondria and ER. The results might be attributed to the fact that both mitochondria and ER contain a high concentration of lipid membranes, which increase the rate of formation of oxidative products of NO, such as nitrogen dioxide [33].…”
Section: Discussionmentioning
confidence: 99%