2011
DOI: 10.1056/nejmoa1105243
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Abstract: Background Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. Methods In nine countries, we enrolled 1763 couples in which one partner was HIV-1–positive and the other was HIV-1–negative; 54% of the subjects were from Africa, and 50% of infected partners were men. HIV-1–infected subjects with CD4 counts between 350 and 550 cells per cubic millimeter were randomly assigned in a 1:1 ratio to receive antire… Show more

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Cited by 6,009 publications
(5,006 citation statements)
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References 33 publications
(34 reference statements)
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“…In the absence of the ability of the public health system to end systemic discrimination towards transwomen, offering hormones and providing an environment where transwomen’s gender identity is respected may be one way to improve linkage to care and increase HIV viral suppression among transwomen. Interventions to better provide medical care for transwomen may affect HIV disease progression within the population, which also have implications for onward HIV transmission [25] and research to best capture the HIV care continuum among transwomen.…”
Section: Discussionmentioning
confidence: 99%
“…In the absence of the ability of the public health system to end systemic discrimination towards transwomen, offering hormones and providing an environment where transwomen’s gender identity is respected may be one way to improve linkage to care and increase HIV viral suppression among transwomen. Interventions to better provide medical care for transwomen may affect HIV disease progression within the population, which also have implications for onward HIV transmission [25] and research to best capture the HIV care continuum among transwomen.…”
Section: Discussionmentioning
confidence: 99%
“…HIV treatment with ARV therapy can substantially decrease morbidity and mortality and reduce the rate of HIV transmission. [33][34][35][36][37][38][39][40] Approximately 16.9% of all HIV-positive individuals are in the U.S. criminal justice system 41 ; therefore, interventions that improve ARV uptake, as well as ARV adherence and persistence after release from jails and prisons have the potential to curtail the HIV epidemic by decreasing HIV transmission to others. This is particularly relevant given the deleterious effect of short-term incarceration and release on virologic outcomes [42][43][44] and the high frequency of self-reported HIV-related risky behaviors of newly released HIV-positive inmates.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, HIV infection is today considered a chronic disease in well treated individuals. The effectiveness of ART has also reduced the risk of transmission to a sexual partner (Cohen et al, 2011; Wawer et al, 2005), a risk which is even questioned to be possible when an individual is well treated with ART (Rodger et al, 2016). ART during pregnancy, suppressing plasma HIV RNA, and mothers refraining from breastfeeding the baby have also been found to significantly reduce the risk of mother-to-child-transmission (MTCT) to a level below 0.5% in well treated individuals (Mandelbrot et al, 2015; Swedish Reference Group for Antiviral Therapy [RAV], 2017).…”
Section: Introductionmentioning
confidence: 99%