2011
DOI: 10.1056/nejmoa1103319
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: BACKGROUND In prospective experimental studies in patients with asthma, it is difficult to determine whether responses to placebo differ from the natural course of physiological changes that occur without any intervention. We compared the effects of a bronchodilator, two placebo interventions, and no intervention on outcomes in patients with asthma. METHODS In a double-blind, crossover pilot study, we randomly assigned 46 patients with asthma to active treatment with an albuterol inhaler, a placebo inhaler, … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

7
196
2
4

Year Published

2012
2012
2018
2018

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 307 publications
(209 citation statements)
references
References 26 publications
7
196
2
4
Order By: Relevance
“…In fact, our results may be analogous to a sham-controlled study of albuterol inhaler for asthma, which demonstrated that while sham acupuncture and placebo inhaler was as effective as an albuterol inhaler in terms of symptom reduction, objective physiological outcomes (i.e. spirometry to assess forced expiratory volume) did demonstrate significant improvement for albuterol (Wechsler et al, 2011); the authors suggested that patient self-report of symptom severity may be less reliable from a clinical management standpoint compared to objective physiological outcomes. Chronic pain disorders similarly lack established biomarkers or objective outcomes (Tracey, 2011).…”
Section: Discussionsupporting
confidence: 70%
“…In fact, our results may be analogous to a sham-controlled study of albuterol inhaler for asthma, which demonstrated that while sham acupuncture and placebo inhaler was as effective as an albuterol inhaler in terms of symptom reduction, objective physiological outcomes (i.e. spirometry to assess forced expiratory volume) did demonstrate significant improvement for albuterol (Wechsler et al, 2011); the authors suggested that patient self-report of symptom severity may be less reliable from a clinical management standpoint compared to objective physiological outcomes. Chronic pain disorders similarly lack established biomarkers or objective outcomes (Tracey, 2011).…”
Section: Discussionsupporting
confidence: 70%
“…In the present study, we extended the understanding of nonconscious cognitions by showing that explicitly conditioned placebo analgesia and nocebo hyperalgesic responses can be activated by nonconscious cues. Our results thereby translate the investigation of nonconscious effects to the clinical realm, by suggesting that health-related responses can be triggered by cues that are not consciously perceived, not only for pain, which is one of the most common reasons for seeking healthcare (23), but also for other medical problems with demonstrated placebo effects, e.g., asthma (24), depression (25), and irritable bowel syndrome (26). Understanding the role of nonconscious processes in placebo/nocebo opens unique possibilities of enhancing clinical care by attending Fig.…”
Section: Discussionmentioning
confidence: 73%
“…Future studies will show whether the present findings can be translated into a clinical setting where nonconscious effects on health-related behavior and treatment outcomes can be further validated. In addition to pain responses, conditioned placebo effects are known to affect a variety of clinical symptoms (24,(45)(46)(47), suggesting that the present findings could be translated to other disciplines than pain. In addition, future studies should establish whether conditioned placebo and nocebo responses could be obtained with the use of nonconscious stimuli also during the acquisition phase of the conditioning procedure.…”
Section: Discussionmentioning
confidence: 79%
“…A recent evaluation of patient-reported outcomes in asthma revealed similar findings which were compared against objective and well-validated measurements of forced expiratory volume in 1 second (FEV1). 53 Patients were administered albuterol, sham acupuncture, or no intervention and asked to rate their improvement as well as undergo measurement of FEV1. While there was significant improvement on albuterol based on FEV1 measurement, there was no benefit to albuterol with a self-reported endpoint which highlights the ongoing need for objective data to conduct similar to IBS validation trials.…”
mentioning
confidence: 99%