Antiplasmodial Flavonoids from<i>Erythrina sacleuxii</i>

Andayi, Andrew; Yenesew, Abiy; Derese, Solomon; Midiwo, Jacob O.; Gitu, Peter M.; Jondiko, O J; Akala, Hosea; Liyala, Pamela; Wangui, Julia; Waters, Norman C.; Heydenreich, Matthias; Peter, Martin G.

doi:10.1055/s-2005-873200

Cited by 47 publications

(38 citation statements)

References 10 publications

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“…These plants are known to be a rich source of bioactive alkaloids (Ghosal et al, 1971;Furukawa et al, 1976;Barakat et al, 1977;Cordell, 1981) and flavonoids, mainly isoflavones, pterocarpans, flavanones and isoflavanones (Chacha et al, 2005). Some of these flavonoids have been found to display a variety of biological activities, such as antimicrobial activity (Mitscher et al, 1987(Mitscher et al, , 1988aChacha et al, 2005;Yenesew et al, 2005), anti-HIV activity (Mckee et al, 1997), antibacterial activity (Tanaka et al, , 2004Sato et al, 2002), anti-inflammatory activity (Njamen et al, 2003(Njamen et al, , 2004 and anti-plasmodial activity (Andayi et al, 2006).…”

Section: Introductionmentioning

confidence: 94%

Antibacterial Pterocarpans from Erythrina subumbrans

Rukachaisirikul

Innok

Aroonrerk

et al. 2007

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 94%

Antibacterial Pterocarpans from Erythrina subumbrans

Rukachaisirikul

Innok

Aroonrerk

et al. 2007

Journal of Ethnopharmacology

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“…Further chromatographic separation of the acetone extract of the root bark by Andayi et al . afforded a new isoflavone, 7-hydroxy-4′-methoxy-3′-prenylisoflavone, named 5-deoxy-3′-prenylbiochanin A ( 34 ) along with known isoflavonoids as the antiplasmodial principles [67]. Flavonoids and isoflavonoids isolated from the stem bark of E. sacleuxii were also tested and showed antiplasmodial activities.…”

Section: Introductionmentioning

confidence: 99%

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Ntie‐Kang

Onguéné

Lifongo

et al. 2014

Malar J

109

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Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery projects targeting malaria often resort to natural sources in the search for lead compounds. A survey of the literature has led to a summary of the major findings regarding plant-derived compounds from African flora, which have shown anti-malarial/antiplasmodial activities, tested by in vitro and in vivo assays. Considerations have been given to compounds with activities ranging from “very active” to “weakly active”, leading to >500 chemical structures, mainly alkaloids, terpenoids, flavonoids, coumarins, phenolics, polyacetylenes, xanthones, quinones, steroids and lignans. However, only the compounds that showed anti-malarial activity, from “very active” to “moderately active”, are discussed in this review.

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“…Pre-clinical data have suggested pharmacological mechanisms (e.g. GABA and serotonin receptor modulation) that may be partially responsible for Scutellaria 's putative effects (Awad et al , 2003; Gafner et al , 2003b; Xu et al , 2006). …”

Section: Introductionmentioning

confidence: 99%

Comparison of the phenolic component profiles of skullcap (Scutellaria lateriflora) and germander (Teucrium canadense and T. chamaedrys), a potentially hepatotoxic adulterant

Lin

Harnly

Upton³

2009

Phytochemical Analysis

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Introduction Scutellaria lateriflora, commonly known as skullcap, is used as an ingredient in numerous herbal products. Unfortunately, it has occasionally been adulterated with Teucrium canadense or T. chamaedrys, commonly known as germander, which contains potentially hepatotoxic diterpenes. Chromatographic profiles of the phenolic components provide a means of distinguishing between these plants and enhancing public safety. Objective To develop a chromatographic method for the identification of Scutellaria lateriflora and two Teucrium species and to quantify the latter as adulterants. Methodology Samples were extracted with aqueous methanol and the extracts were analysed using a standardised LC-DAD-ESI/MS profiling method to obtain their phenolic profiles. Results Skullcap contained primarily flavonoids, while the major phenolic components of the two Teucrium species were the phenylethanoids, verbascoside and teucrioside. Using the phenylethanoids as markers, it was possible to clearly distinguish between the two genus and to determine 5% Teucrium mixed with Scutellaria using either ultraviolet absorption spectrometry or mass spectrometry in the total ion count mode. Using MS in the selective ion monitoring (SIM) mode, 1% Teucrium could be measured. Conclusions This study showed that chromatographic profiling was able to identify Scutellaria and Teucrium, separately and when mixed together.

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Antiplasmodial Flavonoids fromErythrina sacleuxii

Cited by 47 publications

References 10 publications

Antibacterial Pterocarpans from Erythrina subumbrans

Antibacterial Pterocarpans from Erythrina subumbrans

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Comparison of the phenolic component profiles of skullcap (Scutellaria lateriflora) and germander (Teucrium canadense and T. chamaedrys), a potentially hepatotoxic adulterant

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