COVID-19 in Pregnancy: Implication on Platelets and Blood Indices

Nori, Wassan; Hameed, Ban Hadi; Thamir, Asmaa Rajih; Fadhil, Amenah

doi:10.1055/s-0041-1733912

Cited by 12 publications

(15 citation statements)

References 22 publications

(36 reference statements)

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“…Mental health and stress-related tachycardia were also reported in many SARS-CoV-2 patients [ 23 ]. Moreover, the increase in total WBC noticed in seropositive cases points to an underlying inflammatory process where leukocytosis is triggered as part of the primary immune response to inflammation [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…3 % of seropositive cases had dead fetuses, which can be attributed to maternal hypercoagulability state induced by pregnancy, exaggerated by the viral pro-thrombotic effect, added to the fever, and released inflammatory mediators, all of which contribute to thrombosis of placental and umbilical veins, causing fetal death [ 4 , 14 , 25 ]. In a recently published meta-analysis study, the authors studied 1787 seropositive mothers and revealed that only 2.8 % of their neonates tested positive for SARS-CoV-2.…”

Section: Discussionmentioning

confidence: 99%

“…Obstetricians should be able to comprehend the physiologic processes of FHR change that underpin these changes for accurate interpretation and sound clinical judgment [ 12 ]. Earlier in the COVID-19 pandemic, higher maternal death rates were attributed to the rise in CS rates and anesthesia complications in an already compromised maternal inflammatory status [ 13 , 14 ]. Reviewing literature reveals a shift in practice to vaginal birth rather than CS delivery, which is now indicated for obstetrical indications in seropositive mothers [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Can Fetal Heart Lie? Intrapartum CTG Changes in COVID-19 Mothers

Farhan

Nori

Kadir

et al. 2022

J Obstet Gynecol India

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Background COVID-19 infection has raised multiple concerns in pregnant mothers; many questioned the risk of vertical transmission and the implication on the feto-maternal outcome. Cardiotocogrm (CTG) is the principal method to observe intrapartum fetal well-being. This paper aims to verify intrapartum CTG changes seen in seropositive COVID-19 mothers versus healthy controls and looks into their relation to subsequent delivery mode and neonatal outcome. Methods A case–control study recruited 90 pregnant women at the labor word of AL Yarmouk Teaching Hospital. All were term pregnancy admitted for delivery. They were grouped into 2: seropositive COVID-19 confirmed by real-time RT-PCR test (30/90) and healthy controls (60/90). We recorded their demographic criteria, laboratory results, CTG changes, delivery mode, and indication. Results COVID-19 cases showed significantly higher pulse rate, temperature, and leukocyte counts. Cesarian deliveries (CS) were higher in cases versus healthy controls (70 % vs. 53.3 %) and P = 0.45. Analysis of the CS indications showed that abnormal fetal heart tracing accounts for 33.3 % versus 15.6 % (P-value = 0.015) for cases versus healthy controls. 60 % of COVID-19 cases exhibited abnormal CTG changes versus 19.4 % in healthy controls. These changes were primarily fetal tachycardia and reduced variabilities. Conclusions The higher incidence of abnormal CTG in COVID-19 cases, alongside infection signs and symptoms, underlies the exaggerated inflammatory reactions inside the pregnant mother. These inflammatory reactions are the main causes of CTG changes and higher CS rates. Therefore, obstetricians are advised to optimize the maternal condition to rectify reactive CTG changes rather than proceeding into urgent CS. Supplementary Information The online version contains supplementary material available at 10.1007/s13224-022-01663-6.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Can Fetal Heart Lie? Intrapartum CTG Changes in COVID-19 Mothers

Farhan

Nori

Kadir

et al. 2022

J Obstet Gynecol India

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“…Several concerns were raised regarding the viral effect on vulnerable groups, especially pregnant women and newborns. Most of the infections occurred in the third trimester (2). Pregnancy does not seem to enhance the risk of contracting SARS-CoV-2 but increases its severity (3).…”

Section: Introductionmentioning

confidence: 90%

“…The pandemic caused by COVID-19 has cast its shadow on many economic, political, and health aspects. Since the preliminary report of the new coronavirus 2019 due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, 2019, the number of confirmed cases, related mortality, and morbidity have quickly grown (1,2). Several concerns were raised regarding the viral effect on vulnerable groups, especially pregnant women and newborns.…”

Section: Introductionmentioning

confidence: 99%

The dilemma of COVID-19 diagnosis in pregnancy

et al. 2022

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Coronavirus Disease 2019 is a new and rapidly developing health crisis. Ongoing researches are looking at the prevalence and consequences of COVID-19 in the obstetric community and postnatal period. In COVID 19 era, pregnant mothers are prone to infection with the severe acute respiratory syndrome coronavirus 2, with a higher risk of poor pregnancy outcomes. Therefore, an accurate and early diagnosis is a necessity for this vulnerable group. Screening for asymptomatic carriers is a cornerstone to limit the COVID-19 pandemic. It is vital to evaluate patients’ clinical symptoms and epidemiological history carefully. Although the serological test; Polymerase chain reaction RT-PCR can confirm infection, it cannot determine the degree or severity of the illness. Moreover, it has false-negative results. Imaging tests allow exact diagnosis of lung damage, the severity of the disease, and the classification of patients. Comprehensive analyses of serological and imaging data will assist in the formation of an appropriate clinical diagnosis. This review will discuss the updates and critical points in establishing COVID-19 infection in pregnant women with their pros and cons.

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Animal models for COVID-19: advances, gaps and perspectives

Fan

Xiong

et al. 2022

Sig Transduct Target Ther

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COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this century. Since the outbreak in late 2019, animal models have been playing crucial roles in aiding the rapid development of vaccines/drugs for prevention and therapy, as well as understanding the pathogenesis of SARS-CoV-2 infection and immune responses of hosts. However, the current animal models have some deficits and there is an urgent need for novel models to evaluate the virulence of variants of concerns (VOC), antibody-dependent enhancement (ADE), and various comorbidities of COVID-19. This review summarizes the clinical features of COVID-19 in different populations, and the characteristics of the major animal models of SARS-CoV-2, including those naturally susceptible animals, such as non-human primates, Syrian hamster, ferret, minks, poultry, livestock, and mouse models sensitized by genetically modified, AAV/adenoviral transduced, mouse-adapted strain of SARS-CoV-2, and by engraftment of human tissues or cells. Since understanding the host receptors and proteases is essential for designing advanced genetically modified animal models, successful studies on receptors and proteases are also reviewed. Several improved alternatives for future mouse models are proposed, including the reselection of alternative receptor genes or multiple gene combinations, the use of transgenic or knock-in method, and different strains for establishing the next generation of genetically modified mice.

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COVID-19 in Pregnancy: Implication on Platelets and Blood Indices

Cited by 12 publications

References 22 publications

Can Fetal Heart Lie? Intrapartum CTG Changes in COVID-19 Mothers

Can Fetal Heart Lie? Intrapartum CTG Changes in COVID-19 Mothers

The dilemma of COVID-19 diagnosis in pregnancy

Animal models for COVID-19: advances, gaps and perspectives

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