Administrações Orais do Látex da Hancornia speciosa Gomes não aumentam a neoformação óssea

Abstract

Objective The present work aimed to evaluate the systemic effect of H. speciosa latex on bone neoformation. Methods For this, the latex was collected and diluted to 3% and 50%. A total of 28 Wistar rats were submitted to surgery to create a 5 mm diameter defect in the parietal bone. This experiment was conducted in 2 different periods: 1 and 2. For each period, the rats were divided into 3 groups: Control Group, Latex3 Group, and Latex50 Group, which received, respectively, daily administrations of 0.5 mL of distilled water, latex to 3% and latex to 50% by gavage, orally. The rats of periods 1 and 2 were euthanized, respectively, 15 and 30 days after the surgery, and the calvaria was collected. The results were analyzed using the ANOVA and Tukey tests; the significance level was 0.05. Results We show that, in each analyzed period, the experimental groups had the same amount of newly formed bone in the calvaria defect. Conclusion We conclude that daily and oral administrations of H. speciosa latex to 3% and to 50% over a period of 15 and 30 days does not contribute to the increase of the area of the newly formed bone in the calvaria defect.

Látex de Hancornia speciosa Gomes aumenta a mineralização óssea em ratos: Um estudo pré-clínico

“…The histological analysis showed that the oral administration of H. speciosa latex at 50% did not increase the newly-formed bone in the mandibular alveolus or the calvarial defect. These data corroborate other results previously obtained by our team 27 with the oral administration of the latex in another concentration (of 50% and 3%).…”

“…A análise histológica mostrou que a administração oral do látex de H. speciosa a 50% não aumentou o osso recém-formado no alvéolo mandibular ou no defeito calvarial. Esses dados corroboram outros resultados que nossa equipe já obteve anteriormente 27 utilizando outra concentração de látex (50% e 3%) de administração oral.…”