Variables Associated with Endometriosis-related Pain: A Pilot Study using a Visual Analogue Scale

Cozzolino, Mauro; Coccia, Maria Elisabetta; Lazzeri, Giacomo; F, Basile; Troiano, Gianmarco

doi:10.1055/s-0039-1679879

Cited by 22 publications

(17 citation statements)

References 29 publications

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“…Continued reporting a prevalence in their coexistence (30). Note also that chronic pelvic pain, often reported (31,32) as one of the three main types of endometriosis-related pain with an incidence of 40-60% (33), was reported by only about one quarter of the subjects of our study. Nonetheless, in contrast with previous reports, the incidence of urinary disorders and pelvic pain was low.…”

Section: Discussionsupporting

confidence: 44%

Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms

Signorile¹,

Cassano²,

Viceconte³

et al. 2022

In Vivo

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Background: Endometriosis is an estrogendependent and chronic inflammatory gynecological disease due to the presence of ectopic endometrial tissue outside the uterine cavity. This disease affects approximately 10% of the female population. In spite of its relatively high prevalence, information about its pathogenesis, diagnosis, and therapy is not complete. Patients and Methods: We present a retrospective study performed on 4,083 patients with endometriosis, with a focus on symptoms. The archived data were analyzed investigating the distribution of symptoms among patients, the correlation of symptoms with the occupation of the patients, and finally the correlation with the other anamnestic data. Statistical associations between the data for all cases were then considered separately. Results: Chronic fatigue syndrome and dyspareunia were confirmed as being among the main symptoms of endometriosis, together with bowel disorders. On the other hand, we registered a low occurrence of urinary disorders and even of chronic pelvic pain, which is usually considered among the main symptoms of endometriosis. We found an increase in incidence of symptoms starting from the age group 25-29 years up to 40-44 years and, subsequently, a significant decrease in the group aged 55-59 years. For all the symptoms analyzed, we found a higher incidence in employers, graduates and freelancers. Finally, we found a protective effect of the number of gestations on chronic fatigue syndrome. Conclusion: This in-depth study on such a vast cohort of affected patients clarifies some important aspects on the complex symptomatology of this still enigmatic disease. In particular, the study highlights the symptoms most closely related to endometriosis which will help speed up the diagnostic process of patients suffering from this pathology.

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Section: Discussionsupporting

confidence: 44%

Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms

Signorile¹,

Cassano²,

Viceconte³

et al. 2022

In Vivo

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“…The third section identified the characteristics of dysmenorrhea including its onset, duration of pain, severity, associated symptoms, and its impact on daily activities and academic performance. The severity of dysmenorrhea was measured using a 10-point visual analogue scale (VAS), a previously well validated and reliable scale [ 31 , 32 , 36 , 37 ]. The VAS represents the female's perception of the degree of pain, ranging from having no pain to unbearable pain (0–10, respectively).…”

Section: Methodsmentioning

confidence: 99%

Prevalence, risk factors, and management practices of primary dysmenorrhea among young females

et al. 2021

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Background Primary dysmenorrhea (PD) is one of the most common gynecological conditions among young females, which has a significant negative impact on health-related quality of life and productivity. Despite its high prevalence, the evidence is limited regarding the management-seeking practices and its perceived effectiveness among females with PD. Methods This is a cross-sectional study conducted among 550 female students in six universities across Lebanon. The prevalence of PD, associated risk factors, and management-seeking practices were assessed using a self-administered questionnaire. Results The prevalence of PD was 80.9%. Most of the females with PD described their menstrual pain as moderate (56%) to severe (34.6%), which significantly affected their daily activities and studying ability (P < 0.001). The major risk factors associated with PD included heavy menstrual flow (adjusted odds ratio [AOR] = 10.28), family history of PD (AOR = 2.52), history of weight loss attempt (AOR = 2.05), and medical specialization (AOR = 1.663). Only 36.9% of females with PD sought formal medical advice. Most dysmenorrheic females (76.4%) received medications for the management of PD, and remarkably none of them took hormonal contraceptives. Drugs commonly used for PD were mefenamic acid (26.2%), ibuprofen (25%), and paracetamol (11.5%), which were administered when the pain started (58.2%). All medications were significantly effective in reducing the pain score (P = 0.001), and most NSAIDs were more potent than paracetamol in managing PD (P = 0.001). However, no significant difference in adverse effects among medications was revealed. Moreover, no superiority of any individual NSAID for pain relief was established. Nevertheless, mefenamic acid was associated with the lowest risk of abdominal pain (OR: 0.03, P = 0.005) and the highest risk of flank pain (OR = 12, P = 0.02). Conclusions Suboptimal management of PD is practiced among university students in Lebanon. Therefore, health care providers should educate dysmenorrheic females to optimize the self-management support of PD. Furthermore, future research is required to investigate females’ misconceptions about hormonal contraceptives in the management of PD, aiming to raise awareness and correct misconceptions.

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“…Considering the median time since diagnosis and the time of treatment of these cases, a delay in diagnosis was observed. The delayed diagnosis can be explained by atypical clinical pictures, unavailability of complementary tests or lack of suspicion by physicians [6,9,22]. Dysmenorrhea and deep dyspareunia, which were highly prevalent in this study, are the symptoms most commonly reported by patients with endometriosis [3,7,23,24].…”

Section: Discussionmentioning

confidence: 97%

“…In addition to distortion of the pelvic cavity by endometriosis foci, immune cells, prostaglandins, cytokines, and oxidative stress from the disease may explain the association with infertility, in addition to the contribution of mood and anxiety disorders to this condition [5]. Perimenstrual urinary or evacuation symptoms are occasional complaints, especially in the infiltrating form of the disease, in which 5 mm or more of the peritoneum is affected [6].…”

Section: Introductionmentioning

confidence: 99%

Clinical Treatment of Deep Infiltrating Endometriosis – Impacts on Sexual Function

Vieira¹,

Coelho²,

Gomes³

et al. 2021

CMR

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Objectives: Considering the prevalence of endometriosis in reproductive-age women and its negative impact on life quality, the authors of the present research intended to evaluate the impact of clinical treatment on the sexual function of patients with deep infiltrating endometriosis treated at the Endometriosis and Chronic Pelvic Pain Clinic of HSPE-FMO. Methods: A prospective and comparative observational study was conducted between May 2015 and July 2019 in which data from 43 patients with presumed deep endometriosis were analyzed, including age, parity, surgical and obstetric history and Female Sexual Function Index (FSFI questionnaire). Statistical analysis was performed using multiple regression in order to compare the variables. Results: The mean age of the women who were studied was 39.16 years; all patients were symptomatic and most had rectosigmoid endometriosis (65,1%). The median FSFI total score before treatment was 25.06, with 60,5% of the women classified as having a sexual dysfunction. There was a risk for sexual dysfunction to become permanent following clinical treatment when this dysfunction was established previously. The Poisson multiple regression showed that sexual dysfunction before treatment was associated with a lower FSFI total score after treatment and dysfunction before treatment had a direct correlation with final score smaller than 26.55. Considering the FSFI total scores before and after clinical treatment, there was no significant difference in the improvement rate between groups. Conclusions: Most patients did not show improvement in sexual function after clinical treatment.

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Variables Associated with Endometriosis-related Pain: A Pilot Study using a Visual Analogue Scale

Cited by 22 publications

References 29 publications

Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms

Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms

Prevalence, risk factors, and management practices of primary dysmenorrhea among young females

Clinical Treatment of Deep Infiltrating Endometriosis – Impacts on Sexual Function

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