Hearing Disorders in Congenital Toxoplasmosis: A Literature Review

Corrêa, Camila de Castro; Maximino, Luciana Paula; Weber, Silke Anna Theresa

doi:10.1055/s-0037-1605377

Cited by 14 publications

(4 citation statements)

References 18 publications

(19 reference statements)

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“…Permanent hearing loss can be caused by several factors, including exposure to noise, ototoxic drugs, or PCBs, age, congenital or immunological disorders, and other infections [ 44 , 45 , 46 , 47 , 48 , 49 ]. Congenital toxoplasmosis can cause sensorineural hearing loss in humans [ 50 ], but little is known on the specific characteristics of the type and level of hearing loss, or of other disorders possibly involved in the auditory processing [ 51 ]. Histopathological and immunohistochemical studies in infants with congenital toxoplasmosis showed a decreased neuron population and in one individual a significant loss of OHCs, especially severe at the basal turn [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Evidence of Hearing Loss and Unrelated Toxoplasmosis in a Free-Ranging Harbour Porpoise (Phocoena phocoena)

IJsseldijk

Berends

Gröne

et al. 2021

Animals

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Evidence of hearing impairment was identified in a harbour porpoise (Phocoena phocoena) on the basis of scanning electron microscopy. In addition, based on histopathology and immunohistochemistry, there were signs of unrelated cerebral toxoplasmosis. The six-year old individual live stranded on the Dutch coast at Domburg in 2016 and died a few hours later. The most significant gross lesion was multifocal necrosis and haemorrhage of the cerebrum. Histopathology of the brain revealed extensive necrosis and haemorrhage in the cerebrum with multifocal accumulations of degenerated neutrophils, lymphocytes and macrophages, and perivascular lymphocytic cuffing. The diagnosis of cerebral toxoplasmosis was confirmed by positive staining of protozoa with anti-Toxoplasma gondii antibodies. Tachyzoites were not observed histologically in any of the examined tissues. Ultrastructural evaluation of the inner ear revealed evidence of scattered loss of outer hair cells in a 290 µm long segment of the apical turn of the cochlea, and in a focal region of ~ 1.5 mm from the apex of the cochlea, which was compatible with noise-induced hearing loss. This is the first case of concurrent presumptive noise-induced hearing loss and toxoplasmosis in a free-ranging harbour porpoise from the North Sea.

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Section: Discussionmentioning

confidence: 99%

Evidence of Hearing Loss and Unrelated Toxoplasmosis in a Free-Ranging Harbour Porpoise (Phocoena phocoena)

IJsseldijk

Berends

Gröne

et al. 2021

Animals

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“…Sensorineural hearing loss (SNHL) is a common clinical entity in newborns [1,2] and children [3,4]. Pediatric SNHL is an etiologically heterogeneous condition caused by a plethora of genetic [5][6][7] and environmental factors [8][9][10][11][12]. Recent advances in molecular genetics have revolutionized the assessment armamentarium of pediatric SNHL, enabling us to ascertain the etiology in 40-60% of the children with SNHL [13,14].…”

Section: Introductionmentioning

confidence: 99%

The prevalence and demographic features of congenital cytomegalovirus infection in an urban area of East Asia: A population-based study

et al. 2021

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Congenital cytomegalovirus (cCMV) infection is the leading environmental cause of childhood hearing impairment. However, its significance remains largely undocumented in many regions of the world. The purpose of this study was to investigate the prevalence and clinical features of cCMV infection in East Asia. Neonates born at a municipal hospital in Taipei were prospectively recruited and underwent concurrent hearing and CMV screenings. Those who failed the hearing screening or screened positive for CMV were subjected to a focused audiological and/or virological surveillance. The characteristics of the newborns and their mothers were compared between the CMV-positive and CMV-negative groups. Of the 1,532 newborns who underwent concurrent hearing and CMV screenings, seven (0.46%) were positive for cCMV infection. All seven CMV-positive newborns were asymptomatic at birth, and none of them developed hearing or other symptoms during a follow-up period of 14.4±6.3 months. The mothers of the CMV-positive newborns demonstrated higher gravidity (2.4 ± 1.4 vs. 2.1 ± 1.2) and parity (2.0 ± 1.2 vs. 1.6 ± 0.7) than those in the CMV-negative group; however, the difference did not reach statistical significance. The prevalence of cCMV infection in Taipei newborns was 0.46%, which is slightly lower than that of other populations and that of a previous report in the Taiwanese population. The relatively low prevalence in this study might be attributed to the improved public health system and decreased fertility rate in Taiwan.

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“…Some researchers have shown that the consumption of undercooked meat can contribute to T. gondii infection, although it has also been found that freezing at a temperature of -20 °C for 18 to 24 hours destroys the cysts present in contaminated meat [42]. The literature is consistent in demonstrating that the transmission of toxoplasmosis is higher in places where people have poor hygienic habits when preparing food [43,45]. Thus, the information obtained in this study of congenital toxoplasmosis and risk factors for acquiring this disease, verifies reasons for further studies in health centers, not only in the Federal District, throughout Brazil.…”

mentioning

confidence: 98%

“…In a study conducted in São Paulo, the authors suggest that infrequent appointments make it difficult for women to be well informed about the preventive methods for toxoplasma. They also prevent the detection of new cases, making it impossible for an early treatment with spiramycin, which would prevent congenital transmission [43,44]. Another important aspect analyzed in our study concerned the access of pregnant women to basic sanitation and safe drinking water.…”

mentioning

confidence: 99%

Toxoplasmosis Frequency in Pregnant Women Attending Regional Health Centers in the City of Samambaia of the Federal District, Brazil

Er¹,

Cs²,

Silva³

et al. 2018

BJSTR

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Toxoplasmosis is caused by T. gondii, with prevalence from 20 to 90% in the world population. In pregnant women, the presence of fetal infection reaches 40%. The aim of the study was to determine the frequency and risk factors of toxoplasmosis in pregnant women receiving care at health centers in the city of Samambaia in the Federal District. Two groups of women: one group included pregnant women who attended prenatal programs in 2014 using interviews and a printed questionnaire. The other group included pregnant women randomly selected from records in the system of the health centers. These women had had serological tests for toxoplasmosis conducted in 2011, 2012, 2013 and 2014. A total of 414 pregnant women participated in the study: 200 that were interviewed and 214 by way of secondary data obtained between 2011 and 2014. Of these secondary data, the prevalence of susceptible pregnant women was 39%, those immune were 34% and those infected during pregnancy, 27%. They were between 21-25 years of age, little education and poor information about prevention to toxoplasmosis. The prevalence of immune susceptible and infected pregnant women varies by age, level of education and information about toxoplasmosis in the first pregnancy.

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Hearing Disorders in Congenital Toxoplasmosis: A Literature Review

Cited by 14 publications

References 18 publications

Evidence of Hearing Loss and Unrelated Toxoplasmosis in a Free-Ranging Harbour Porpoise (Phocoena phocoena)

Evidence of Hearing Loss and Unrelated Toxoplasmosis in a Free-Ranging Harbour Porpoise (Phocoena phocoena)

The prevalence and demographic features of congenital cytomegalovirus infection in an urban area of East Asia: A population-based study

Toxoplasmosis Frequency in Pregnant Women Attending Regional Health Centers in the City of Samambaia of the Federal District, Brazil

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