Hearing Loss, Dizziness, and Carbohydrate Metabolism

Abstract

Introduction Metabolic activity of the inner ear is very intense, and makes it sensitive to changes in the body homeostasis. This study involves a group of patients with inner ear disorders related to carbohydrate metabolism disturbances, including hearing loss, tinnitus, dizziness, and episodes of vertigo.Objectives To describe the symptoms of metabolic inner ear disorders and the examinations required to establish diagnoses. These symptoms are often the first to allow for an early diagnosis of metabolic disorders and diabetes.Methods Retrospective study of 376 patients with inner ear symptoms suggestive of disturbances of carbohydrate metabolism. The authors present patientś clinical symptoms and clinical evaluations, with emphasis on the glucose and insulin essays.Results Authors based their conclusions on otolaryngological findings, diagnostic procedures and treatment principles. They found that auditory and vestibular symptoms usually occur prior to other manifestations of metabolic changes, leading to an early diagnosis of hyperinsulinemia, intestinal sugar malabsorption or diabetes. Previously undiagnosed diabetes mellitus type II was found in 39 patients.Conclusions The identification of carbohydrate metabolism disturbances is important not only to minimize the patients' clinical symptoms, but also to help maintain their general health.

Impaired Glycolysis Promotes Alcohol Exposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling

“…We next investigated the underlying molecular mechanism by which alcohol exposure regulates cytotoxicity via apoptosis in HEI-OC1 cells. Since the dysregulation of glucose metabolism has been linked to hearing loss [9,10], we examined whether the inhibition of glycolysis could be a critical metabolic change for alcohol exposure-induced apoptosis in HEI-OC1 cells. We first analyzed the changes of glycolytic activity by alcohol exposure in HEI-OC1 cells.…”

“…In four HK isozymes (HK1-4), the expression of HK1 has been identified in various cell types [5][6][7][8]. The dysregulation of glucose metabolism has been linked to hearing loss [9,10].…”

Controle postural em indivíduos com diabetes mellitus do tipo 2 com vertigem, tontura e/ou desequilíbrio

“…Little information is available in the literature about the interference of hyperglycemia and T2DM in the human body balance system; findings point to a possible correlation between peripheral vestibular diseases and insulin blood levels and glycemia (3,16) . Changes in blood glycemia concentration and particularly of blood insulinemia change the chemical structure of endolymph and can produce vertigo and dizziness (4) . Deterioration of sensorial functions related to body balance, particularly in challenging conditions, was also identified in T2DM without neuropathy; a dysfunction in any of the three sensory systems, vestibular, visual, and somatosensory, can cause significant impairment to maintenance of postural control (17) .…”

“…Although the physiopathology of vestibular sensory organ impairment in diabetic individuals is not clear, hyperglycemia may be related to the clinical signs of peripheral vestibulopathy, body balance problems, functional incapacitation, and falls (2,3) . Dysglycemic patients may suffer from hearing and vestibular symptoms, such as vertigo, floating sensation, hearing loss, tinnitus, aural fullness, discomfort with intense sounds, and weakness, sweating and diarrhea (4) . Postural imbalance and falls are very frequent in people with diabetes (2,(5)(6)(7) .…”

Dizziness in a Tertiary Care Centre in Sikkim: Our Experience and Limitations

“…Metabolic and endocrine abnormalities are important cause of dizziness and need to be excluded in patient presenting with dizziness. Thyroid dysfunction more commonly hypothyroidism has been diagnosed in almost 10% of cases of sudden onset dizziness [23][24][25]. The association of dizziness with refractive error or visual abnormality was reviewed by Armstrong et al [26] and a positive correlation was found.…”