The aqueous extract of<i>Olea europaea</i>leaves protects from haematotoxicity and kidney damage induced by diclofenac in Swiss albino mice

Soussi, Raouya; Hfaïedh, Najla; Sakly, Mohsen; Rhouma, Khémaïs Ben

doi:10.1039/c9ra01670h

Cited by 8 publications

(2 citation statements)

References 31 publications

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“…35 The nephroprotective effect of oleuropein and hydroxytyrosol extracted from Tunisian olive leaf extract have been investigated in rats treated with bisphenol A. 36 In recent study, Soussi et al 37 found that the aqueous extract of Tunisian O. europaea leaves protected against kidney damage induced by diclofenac in mice.…”

Section: Olea Europeamentioning

confidence: 99%

Tunisian Nephroprotective Plants: A Review

Wannes¹,

Tounsi²

2022

J Explor Res Pharmacol

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In Tunisian folk medicine, several herbs are prescribed for reducing renal damage and to avoid kidney related complications. These can be of immense value in combating renal damage. In this review, we provide a description of the current literature on the use of indigenous herbs as alternative medicine for treating renal damage. The aim of this review was to collect information on promising active phytoconstituents such as organosulfur compounds, polyphenols, terpenes, alkaloids phenylpropanoids, and polysaccharides from Tunisian plants that have been scientifically examined for their nephroprotective capacities. Twenty-nine Tunisian medicinal plants have been reported for their significant nephroprotective activities against renal toxicities in animal models. Lamiaceae was the most commonly used Tunisian plant family used for renal protection. The leaves were maximally used for nephroprotection compared to the other plant parts. Nephrotoxicity is commonly the result of several nephrotoxins. Many studies have focussed on drug-caused renal failure which is one of the major problems in medical practice. Other studies focused on other important nephrotoxicity factors, including drugs and industrial chemicals. This literature review highlights the use of some medicinal plants as nephroprotective agents. To defend against this nephrotoxicity, some medicinal plants, known as nephroprotective agents, have been highlighted in this review.

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Section: Olea Europeamentioning

confidence: 99%

Tunisian Nephroprotective Plants: A Review

Wannes¹,

Tounsi²

2022

J Explor Res Pharmacol

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“…Olive ( Olea europaea L.) fruits and leaves have traditionally been used as food additives, functional foods, and pharmaceutical purposes (Bouaziz, Grayer, Simmonds, Damak, & Sayadi, 2005; Granato, Nunes, & Barba, 2017; Soussi, Hfaiedh, Sakly, & Rhouma, 2019). Olives contain considerably high amounts of phenolic antioxidant compounds, including oleuropein and hydroxytyrosol.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the antioxidant profiles of olive fruit and leaf extracts against five reactive oxygen species as measured with a multiple free‐radical scavenging method

Sueishi

Nii

2020

Journal of Food Science

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Olive fruits and leaves are recognized to have great potential as natural sources of antioxidants. The major phenolic antioxidant component in these plant tissues is oleuropein. The antioxidant activity of olive fruits and leaves was evaluated in this study using multiple free‐radical scavenging (MULTIS) methods, wherein we determined the scavenging abilities of different extracts against five reactive oxygen species (ROS; HO·, O2−·, RO·, t‐BuOO·, and 1O2). Raw olive fruits taste bitter and are inedible without undergoing a debittering treatment. Following the NaOH‐debittering process, the radical scavenging activity of olives decreased by 90%. The MULTIS measurements indicated that oleuropein and hydroxytyrosol are responsible for the radical scavenging activity of olive fruits. Furthermore, we evaluated the radical scavenging profiles of olive leaf extracts against five ROS and found significant seasonal variations in their antioxidant activities. Leaves picked in August possessed greater radical scavenging abilities (180% to 410% for different ROS) than those picked in the cold season (December and February). In roasted olive leaves, we found marked increases (230% to 300% and 180% to 220%) in the antioxidant activities of Maillard reaction products against RO· and t‐BuOO·, respectively. This study presented a useful comparative analysis of the antioxidant capacities of food against various types of ROS. Practical Application In this study, we evaluated the natural antioxidant activity of olive fruits and leaves against five reactive oxygen species (ROS). We found characteristic differences in the antioxidant profiles of different olive tissues, which varied after different treatments (debittering [fruit], drying [leaf], and roasting [leaf]). Comparative studies of the antioxidant capacities of foods against various ROS are useful to improve the functionality of food products.

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Phenolic profile, safety, antioxidant and anti-inflammatory activities of wasted Bunium ferulaceum Sm. aerial parts

Deghima

Righi²,

Rosales-Conrado³

et al. 2022

Food Research International

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The aqueous extract ofOlea europaealeaves protects from haematotoxicity and kidney damage induced by diclofenac in Swiss albino mice

Abstract: Olea europaea leaves are one of the most widely used by-products in traditional medicine due to their biological properties.

Cited by 8 publications

References 31 publications

Tunisian Nephroprotective Plants: A Review

Tunisian Nephroprotective Plants: A Review

A comparative study of the antioxidant profiles of olive fruit and leaf extracts against five reactive oxygen species as measured with a multiple free‐radical scavenging method

Phenolic profile, safety, antioxidant and anti-inflammatory activities of wasted Bunium ferulaceum Sm. aerial parts

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