2014
DOI: 10.1039/c4fo00187g
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Abstract: Copyright: Zhao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Alisol B 23-acetate (AB23A), a natural triterpenoid from the rhizome of Alisma orientale, a Chinese medicinal herb, has multiple physiological activities including anticancer. However, its effect on human colon cancer and the under… Show more

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Cited by 79 publications
(66 citation statements)
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“…In the present study, the significantly increased MDA levels following 5-FU treatment (+45%; Fig. 4A) compared to the levels in untreated C26 cells, could account for 5-FU cytotoxicity on C26 cells, as several studies already demonstrated that an increased oxidative stress over the physiological range induced inhibition of cell proliferation and finally cell death via ROS-induced apoptosis (40,42,43).…”
Section: Discussionmentioning
confidence: 79%
“…In the present study, the significantly increased MDA levels following 5-FU treatment (+45%; Fig. 4A) compared to the levels in untreated C26 cells, could account for 5-FU cytotoxicity on C26 cells, as several studies already demonstrated that an increased oxidative stress over the physiological range induced inhibition of cell proliferation and finally cell death via ROS-induced apoptosis (40,42,43).…”
Section: Discussionmentioning
confidence: 79%
“…More recently (9), HT has been shown to protect peripheral blood mononuclear cells from H 2 O 2 -induced oxidative DNA damage, and hepatocellular carcinoma Hep G2 against ER-stress (32). In colon cancer cells, HT has been shown to generate ROS leading to apoptotic cell death and mitochondrial dysfunction (33). Even in prostate cancer PC3 cells, there is evidence for ROS generation by HT, leading to induction of apoptosis (19).…”
Section: Discussionmentioning
confidence: 99%
“…Anti-tumor activity of HT has been evidenced by several in vitro studies. In the last five years, it has been reported that treatments with HT exerted anti-proliferative effects on DLD1 human colon cells [71], TFK-1 and KMBC human cholangiocarcinoma cells and GBS-SD human gallbladder cancer cells [72] and hepatocellular carcinoma cells (HepG2, Hep3B, SK-HEP-1 and Huh-7) [73], as well as on breast (MDA and MCF-7), prostate (LNCap and PC3) and colon (SW480 and HCT116) cancer cell lines [74]. However, the magnitude of these anti-proliferative effects have been reported to depend on cell type; one of the studies on prostate cancer cells showed more resistance to growth inhibition respect than breast and colon cancer cells [74].…”
Section: Olive Oil and Phenolic Compoundsmentioning
confidence: 99%
“…However, the magnitude of these anti-proliferative effects have been reported to depend on cell type; one of the studies on prostate cancer cells showed more resistance to growth inhibition respect than breast and colon cancer cells [74]. Anti-tumor effects of HT could also reside in its reported capacity to reduce cell viability and/or promote apoptotic cell death on human cholangiocarcinoma (TFK-1 and KMBC) [72], colon cancer (DLD1) [71], gallbladder cancer (GBS-SD) [72], hepatocellular carcinoma (HepG2, Hep3B, SK-HEP-1 and Huh-7) [73] and papillary (TPC-1, FB-2) and follicular (WRO) thyroid cancer cells [75] (Figure 1, Table 1). …”
Section: Olive Oil and Phenolic Compoundsmentioning
confidence: 99%
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