2004
DOI: 10.1039/b302845c
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Abstract: Oligonucleotides have been synthesized on hydrogen-terminated Si(111) and porous silicon using surface hydrosilation of difunctional molecules (1,(omega)-dimethoxytritylundecenol) to produce a monolayer bearing suitable reactive groups to allow automated solid-phase DNA synthesis. The absence of an intervening oxide enables electrochemical characterisation of the surface-bound oligonucleotides. Complementary sequences to the DNA synthesized on Si(111) undergo hybridisation at the surface and a straightforward … Show more

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Cited by 53 publications
(40 citation statements)
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“…Although the particles contain a little oxide from their preparation, the alkyl monolayer protects the Si core and they are not oxidized further under ambient conditions. 6 The reaction used to prepare the capping monolayer is sufficiently general to allow manipulation of the chemical functionality on the particle surface, e.g., for synthesis of DNA strands. 6 However, it is also important to characterize the physical properties, especially the luminescence, of these systems because the utility of the particles depends on their luminescence upon insertion into biological cells.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Although the particles contain a little oxide from their preparation, the alkyl monolayer protects the Si core and they are not oxidized further under ambient conditions. 6 The reaction used to prepare the capping monolayer is sufficiently general to allow manipulation of the chemical functionality on the particle surface, e.g., for synthesis of DNA strands. 6 However, it is also important to characterize the physical properties, especially the luminescence, of these systems because the utility of the particles depends on their luminescence upon insertion into biological cells.…”
mentioning
confidence: 99%
“…Recently, several groups, including ourselves, have prepared alkyl-passivated silicon nanocrystals. [5][6][7][8][9][10][11][12][13][14][15][16] These are SiNCs whose surface is capped by a monolayer of saturated hydrocarbon molecules and anchored to the Si core via covalent Si-C bonds. Although the particles contain a little oxide from their preparation, the alkyl monolayer protects the Si core and they are not oxidized further under ambient conditions.…”
mentioning
confidence: 99%
“…After synthesis, for example in micron-sized controlled pore glass (CPG), the DNA is cleaved from the template and collected. While there have been limited reports in the literature on DNA synthesis in porous silicon templates 11,12,13,14 , we presented a first report of in-situ DNA synthesis within a mesoporous silicon optical waveguide structure for label-free sensing. After synthesis, the porous silicon template was not removed like a CPG substrate 15 ; it remains as an active, functionalized sensing platform.…”
Section: Previous Work On In-situ Dna Synthesismentioning
confidence: 99%
“…Figure 3(b) is a schematic structure of the alkylated Si NC. The prepared alkylated Si NCs can be redispersed in organic solvents and cast as a film [11][12][13].…”
Section: Electrochemical Etching and Ultrasonicationmentioning
confidence: 99%