2017
DOI: 10.1038/s41540-017-0034-z
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Salmonella enterica is a prominent bacterial pathogen with implications on human and animal health. Salmonella serovars could be classified as gastro-intestinal or extra-intestinal. Genome-wide comparisons revealed that extra-intestinal strains are closer relatives of gastro-intestinal strains than to each other indicating a parallel evolution of this trait. Given the complexity of the differences, a systems-level comparison could reveal key mechanisms enabling extra-intestinal serovars to cause systemic infec… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
23
0

Year Published

2017
2017
2021
2021

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 29 publications
(23 citation statements)
references
References 103 publications
(98 reference statements)
0
23
0
Order By: Relevance
“…Mutations in transcriptional regulators and regulatory sequences have the potential to have a broad ranging impact on traits of the organism. Indeed, pathovars of Salmonella have diverse regulatory networks, and are also likely to play an important role in the evolution of Salmonella [32] . For example, the PhoP regulon, which includes ∼3% of the S .…”
Section: The Significance Of Within-host Evolutionmentioning
confidence: 99%
See 1 more Smart Citation
“…Mutations in transcriptional regulators and regulatory sequences have the potential to have a broad ranging impact on traits of the organism. Indeed, pathovars of Salmonella have diverse regulatory networks, and are also likely to play an important role in the evolution of Salmonella [32] . For example, the PhoP regulon, which includes ∼3% of the S .…”
Section: The Significance Of Within-host Evolutionmentioning
confidence: 99%
“…Typhi lost nearly 5% (209 genes) of its original coding capacity during the process of adaptation to the human host and loss of virulence for alternative hosts [14] . Genome degradation impacted many functions, including genes involved in anaerobic metabolism 31 , 32 required for outgrowth of Salmonella in the inflamed intestine during gastroenteritis [33] . Since inflammation in the intestine is not a common pathology in typhoid fever , the energy expense of expressing these genes led to reductive evolution.…”
Section: Within-host Evolution Inferred From Host Adaptation Of mentioning
confidence: 99%
“…However, in the other PBIN cliques we also observed the co-occurrence of phage species isolated from different environmental sources (e.g., Mtkari and Black Sea). This could happen if different environmental sites share similar microbial isolates but that their geographic separation or different community niches facilitated local coevolution to take place, which enabled divergences in functional interactions [ 46 , 53 , 54 ]. Overall, nestedness and modularity are not mutually exclusive; there is evidence of trade-offs between the two processes [ 55 , 56 ], and nested patterns could form within modules [ 10 , 57 , 58 ].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, recent studies of the interaction between Salmonella and the host have defined effector-specific cellular reprogramming and options for drug discovery [15, 16]. The development of network resources (e.g., SalmoNet) for biochemical modeling, host-pathogen interaction studies, drug-discovery, experimental validation of novel interactions, and information to reveal new pathological mechanisms improves our understanding of Salmonella pathogenesis [17]. To uncover such information, mass spectrometry-based proteomics provides a robust, sensitive, and unbiased platform for profiling protein-level differences in complex biological samples [18].…”
Section: Introductionmentioning
confidence: 99%